| Project/Area Number |
23890027
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | ドラッグデリバリーシステム / 徐放薬 / 鼻粘膜 / 臨床試験 / リドカイン / 正常粘膜 / クロロホルム / PLGA / ビーグル犬 / 臨床応用 / 尿道カテーテル / 抜歯後疼痛 / Drug Delivery System |
|---|
| Research Abstract |
The controlled release- lidocaine sheet significantly raised mean pain thresholds in a nasal mucous membrane compared with that of preadministration more than 72 hours. Feeling a pain by some pressure stimulation suggested that lidocaine of the component could not reach subcutaneous tissue, but only an outer layer of a mucous membrane. As for side effects, almost all had reactive serous rhinorrhea, but obvious serious adverse events such as a liver injury, a renal injury, pancytopenia and the other were not observed. It may be possible to lead a single administration of the controlled release- lidocaine sheet to the simple and effective postoperative analgesia with few side effects in future.
|
