Selective activation of carboxylic acids by developing novel catalysts
| Project/Area Number |
23890034
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIMIZU Yohei 東京大学, 大学院・薬学系研究科, 助教 (60609816)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | カルボン酸 / ボロン酸 / 触媒 / アルドール反応 / 選択的活性化 / 立体選択的 / ホウ素 / 四級炭素 |
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| Research Abstract |
We found that aldol reaction using carboxylic acids as substrates could be proceeded under mild condition by activating with an equivalent of borane. In addition, the usage of dummy ligands could tune the reactivity and selectivity.
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Report
(3 results)
Research Products
(19 results)
