| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
To understand intracellular trafficking of membrane glycoprotein (G) of nipah virus, intracellular localization of G expressed in cultured cells was analyzed. G localized in endoplasmic reticulum (ER) and golgi apparatus, suggesting that G is transported through the regular intracellular trafficking pathway of membrane proteins of the hosts. Deletion mutant analysis further suggested that outer membrane region contributes to the transport of G from ER to golgi apparatus. These findings are important clues to understand the intracellular trafficking of the nipah virusmembrane protein.
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