Elucidation of the mechanism of toxic metal and radiation-induced disease onset using stress signaling-deficient mice
| Project/Area Number |
23890049
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
IWATSUKI Mamiko 東京医科歯科大学, 難治疾患研究所, 特任助教 (10609689)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 環境中有害物質 / 毒性金属 / ノックアウトマウス / ストレスシグナル / メチル水 / メチル水銀 / カドミウム / マイクロアレイ / パスウェイ解析 |
|---|
| Research Abstract |
Mkk7flox/flox Synapsin-Cre mice were made and exposed with methyl mercury. To examine cell proliferation and apoptosis of brain neurons, we did Nissl stain, BrdU incorporation, TUNEL and active Caspase stains. Furthermore, we did cDNA microarrayof the knockout mice. We are now analyzing these results.
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Report
(3 results)
Research Products
(4 results)
