Development of the novel therapeutic strategy using the collateral circulation activated by cerebral arteriogenesis
| Project/Area Number |
23890052
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MIKI Kazunori 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00536823)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 動脈新生 / 脳梗塞 / 側副血行 / 脳主幹動脈閉塞 / arteriogenesis / 脳動脈新生 / 脳血管障害 / 齧歯類モデル |
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| Research Abstract |
To evaluate the collateral circulation activated by cerebral arteriogenesis, we established the visualization of the leptomeningial l artery in the chronic cerebral hypoperfusion mouse mode using the Latex-carbon ink fixation methods. We investigated the aretriogenesis with PCNA staining, and successfully found the promoting the collateral circulation resulted from arteriogenesis in acute stage of cerebral ischemia.We also established the non-invasive MRI methods to evaluate the collateral circulation in acute stroke patients and reported these collateral sign have an important prognostic value in acute ischemic stroke of proximal arterial occulusion.
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Report
(3 results)
Research Products
(12 results)
