Physiological roles for microRNAs in bone remodeling
| Project/Area Number |
23890053
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
INOSE Hiroyuki 東京医科歯科大学, 医学部附属病院, 助教 (30615711)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 骨 / 軟骨代謝学 / マイクロRNA / 骨芽細胞分化 / 骨代謝 / 分子生物学 |
|---|
| Research Abstract |
We identified members of the miR-34 family as regulators of osteoblast proliferation and differentiation. Osteoblast-specific gain- and loss-of-function experiments revealed that miR-34 affected bone mass accrual. Theseresults indicate that microRNA is a physiological regulatory factor of bone remodeling.
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Report
(3 results)
Research Products
(5 results)
