Physiological roles for microRNAs in bone remodeling

• Project/Area Number: 23890053
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: INOSE Hiroyuki 東京医科歯科大学, 医学部附属病院, 助教 (30615711)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 骨 / 軟骨代謝学 / マイクロRNA / 骨芽細胞分化 / 骨代謝 / 分子生物学

Research Abstract

We identified members of the miR-34 family as regulators of osteoblast proliferation and differentiation. Osteoblast-specific gain- and loss-of-function experiments revealed that miR-34 affected bone mass accrual. Theseresults indicate that microRNA is a physiological regulatory factor of bone remodeling.

Research Products

• [Journal Article] miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2 (2012)
  • Author(s): WEI JIANWEN
  • Journal Title: The Journal of Cell Biology Volume: 197 Issue: 4 Pages: 509-521
  • DOI: 10.1083/jcb.201201057
  • Peer Reviewed
• [Journal Article] Efficacy of serotonin inhibition in mouse models of bone loss (2011)
  • Author(s): Hiroyuki Inose
  • Journal Title: Journal of Bone and Mineral Research Volume: 26 Issue: 9 Pages: 2002-2011
  • DOI: 10.1002/jbmr.439
  • Peer Reviewed
• [Journal Article] miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2
  • Author(s): JIANWEN WEI, YU SHI, LIFUA ZHENG, BIN ZHOU, HIROYUKI INOSE, JI WANG, EDWARD GUO, RUDOLF GROSSCHEDL, GERARD KARSENTY
  • Journal Title: Journal of Cell Biology Volume: Vol.197,No.4 Pages: 509-521
  • Peer Reviewed
• [Presentation] Regulation of osteoblast differentiation by microRNA (2012)
  • Author(s): HIROYUKI INOSE
  • Organizer: GCOE international research day
  • Place of Presentation: Tokyo medical and dental university
  • Year and Date: 2012-10-30
• [Presentation] 頚椎後縦靭帯骨化症の長期成績 (2011)
  • Author(s): 猪瀬弘之
  • Organizer: 脊柱靭帯骨化症に関する調査研究班 平成23年度第2回班会議
  • Place of Presentation: 慶應義塾大学医学部
  • Year and Date: 2011-11-05