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Physiological roles for microRNAs in bone remodeling

Research Project

Project/Area Number 23890053
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

INOSE Hiroyuki  東京医科歯科大学, 医学部附属病院, 助教 (30615711)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords骨 / 軟骨代謝学 / マイクロRNA / 骨芽細胞分化 / 骨代謝 / 分子生物学
Research Abstract

We identified members of the miR-34 family as regulators of osteoblast proliferation and differentiation. Osteoblast-specific gain- and loss-of-function experiments revealed that miR-34 affected bone mass accrual. Theseresults indicate that microRNA is a physiological regulatory factor of bone remodeling.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB22012

    • Author(s)
      WEI JIANWEN
    • Journal Title

      The Journal of Cell Biology

      Volume: 197 Issue: 4 Pages: 509-521

    • DOI

      10.1083/jcb.201201057

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of serotonin inhibition in mouse models of bone loss2011

    • Author(s)
      Hiroyuki Inose
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 26 Issue: 9 Pages: 2002-2011

    • DOI

      10.1002/jbmr.439

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2

    • Author(s)
      JIANWEN WEI, YU SHI, LIFUA ZHENG, BIN ZHOU, HIROYUKI INOSE, JI WANG, EDWARD GUO, RUDOLF GROSSCHEDL, GERARD KARSENTY
    • Journal Title

      Journal of Cell Biology

      Volume: Vol.197,No.4 Pages: 509-521

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Regulation of osteoblast differentiation by microRNA2012

    • Author(s)
      HIROYUKI INOSE
    • Organizer
      GCOE international research day
    • Place of Presentation
      Tokyo medical and dental university
    • Year and Date
      2012-10-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 頚椎後縦靭帯骨化症の長期成績2011

    • Author(s)
      猪瀬弘之
    • Organizer
      脊柱靭帯骨化症に関する調査研究班 平成23年度第2回班会議
    • Place of Presentation
      慶應義塾大学医学部
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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