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The effect of common anesthetic agents to the developing mouse brain

Research Project

Project/Area Number 23890054
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SATOMOTO Maiko  東京医科歯科大学, 医学部附属病院, 助教 (10611551)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords幼若脳 / 麻酔薬 / アポトーシス / 学習障害
Research Abstract

Early exposure to general anesthesia causes widespread apoptotic neurodegeneration in the developing rodents and rhesus monkeys brain.In this study, we observed that preinjection of nicotine markedly reduced neuronal apoptosis caused by sevoflurane exposure in the developing brain.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] レスベラトロールのセボフルラン曝露前投与は、幼若なマウス脳へのアポトーシス誘導を阻止できない

    • Author(s)
      里元麻衣子、伊藤裕之、内田篤治郎、槇田浩史
    • Journal Title

      麻酔

      Volume: (in press)

    • NAID

      40019815014

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 麻酔と小児の神経発達2012

    • Author(s)
      山内(里元)麻衣子
    • Organizer
      日本臨床麻酔学会第32回シンポジウム
    • Place of Presentation
      ビックパレットふくしま(福島県郡山市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 麻酔と小児の神経発達2012

    • Author(s)
      山内(里元)麻衣子
    • Organizer
      日本臨床麻酔学会第32回シンポジウム
    • Place of Presentation
      ビックパレットふくしま(福島県郡山市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 幼若なマウス脳へのセボフルラン曝露と成長後の学習障害及び社会性障害に対する検討2011

    • Author(s)
      山内麻衣子
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 幼若なマウス脳へのセボフルラン曝露と成長後の学習障害及び社会性障害に対する検討2011

    • Author(s)
      山内(里元)麻衣子
    • Organizer
      日本麻酔科学会代58回学術集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Related Report
      2012 Final Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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