| Project/Area Number |
23890057
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
AOYAMA Norio 東京医科歯科大学, 歯学部附属病院, 医員 (30611024)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 自然科学 / 歯学 / 歯周病 / 細菌 / 循環器疾患 / 大動脈瘤 / MMP / TLR / 炎症 / 感染 / マトリックスメタロプロテイナーゼ / Toll様受容体 |
|---|
| Research Abstract |
From the results of this study, the development of aortic aneurysms after P. gingivalis infection was inhibited in TLR-2 deficient mice. MMP-2 and MMP-9 production in abdominal aorta extremely decreased in TLR-2 deficient mice, which was seemed to inhibit aneurysmal expansion. In conclusion, the recognition of periodontal bacteria by TLR-2 may induce systemic inflammation, overexpression of MMPs in aorta, and finally the development of abdominal aortic aneurysms.
|
