| Project/Area Number |
23890058
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
EBE Noriko 東京医科歯科大学, 歯周病学分野, 医員 (20611099)
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| Research Collaborator |
YOKOYAMA Miki 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (70191533)
ISEKI Sachiko 東京医科歯科大学, 大学院・医歯学総合研, 教授 (80251544)
RAJAPAKSHE R.M.A.R 東京医科歯科大学, 大学院・医歯学総合研究科, 大学院生
IZUMI Yuichi 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (60159803)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯周免疫機能学 / 酸化ストレス / TRX1(チオレドキシン 1) / Txnip(thioredoxin interacting protein) / ポケット上皮 / TRX / 組織の酸化状態 / ROS / 歯周ポケット / Trx1 / Txnip / IL-1β |
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| Research Abstract |
Oxidative stress exists in the periodontal pocket side with periodontal patients. We used TRX1 antibody as an oxidative marker. TRX1 was expressed in gingival epithelium, pocket epithelium and T cells under the periodontal pocket epithelium. Especially, TRX1 expression was increased in periodontal patients compared with healthy patients. In vitro study, we have used Ca9-22 cells (gingival epithelial cell line). Further study, it is necessary to use T cells. In the periodontal pocket side at acute inflammation, these oxidative tissues may be involved in the pathogenesis periodontal disease.
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