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Studies on regulation of autophagosome formation by kinases andphosphatases

Research Project

Project/Area Number 23890059
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionTokyo Institute of Technology

Principal Investigator

ARAKI Yasuhiro  東京工業大学, フロンティア研究機構, 特任助教 (60345254)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsオートファジー / リン酸化 / キナーゼ / ホスファターゼ / 蛋白質分解 / 酵母 / PI3キナーゼ / Vps34 / Atg14 / 蛋白質 / 細胞 / シグナル伝達 / 脂質 / ストレス
Research Abstract

Autophagy is a conserved eukaryotic process of vacuolar/lysosomal-mediated degradation targeting proteins and organelles. Autophagy is characterized by the formation of a cytosolic double-membrane structure, the autophagosome. The molecular mechanisms underlying the process of autophagy remain to be elucidated. Here, I demonstrate that Atg1 kinase, the substrates of which were unknown, phosphorylates Atg13 and Vps34. In addition, I identify a novel component of the PI3 kinase complex, Atg38. Atg38 is required for the integrity of this complex.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] オートファジーを長き眠りからめざめさせた酵母2012

    • Author(s)
      荒木保弘、大隅良典
    • Journal Title

      ライフサイエンス領域融合レビュー

      Volume: e005 Pages: 1-10

    • Related Report
      2012 Final Research Report
  • [Journal Article] Awakening the hibernation of autophagy research using yeast2012

    • Author(s)
      荒木保弘
    • Journal Title

      Leading Author's

      Volume: 1 Pages: e005

    • DOI

      10.7875/leading.author.1.e005

    • Related Report
      2012 Annual Research Report
  • [Journal Article] The CENP-A chaperone Scm3 becomes enriched at kinetochores in anaphase independently of CENP-A incorporation.2011

    • Author(s)
      Luconi L., Araki Y., Erlemann S. and Schiebel E
    • Journal Title

      Cell Cycle

      Volume: 10 Pages: 3369-3378

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] p25 is a novel component required for autophagy-specific PI3K complex integrity in yeast2012

    • Author(s)
      荒木保弘、Wei-chi Ku、石濱泰、大隅良典
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡、福岡県
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of a novel component required for autophagy-specific PI3K complex integrity in yeast2012

    • Author(s)
      Yasuhiro Araki、Wei-chi Ku、Yasushi Ishihama、Yoshinori Ohsumi
    • Organizer
      The 6th International Symposium on Autophagy 2012
    • Place of Presentation
      Bankoku Shinyokan,Okinawa
    • Related Report
      2012 Final Research Report
  • [Presentation] p25 is a novel component required for autophagy-specific PI3K complex integrity in yeast2012

    • Author(s)
      荒木保弘
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of a novel component required for autophagy-specific PI3K complex integrity in yeast2012

    • Author(s)
      Yasuhiro Araki
    • Organizer
      The 6th International Symposium on Autophagy 2012
    • Place of Presentation
      Bankoku Shinyokan, Okinawa
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of targets of the Atg1 protein kinase in autophagy2011

    • Author(s)
      荒木保弘
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of targets of the Atg1 protein kinase in autophagy2011

    • Author(s)
      荒木保弘、Wei-chi Ku、石濱泰、大隅良典
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.ohsumilab.aro.iri.titech.ac.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks] 東京工業大学フロンティア研究機構大隅研究室

    • URL

      http://www.ohsumilab.aro.iri.titech.ac.jp/

    • Related Report
      2012 Annual Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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