| Project/Area Number |
23890061
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
MIKAMI Emi 新潟大学, 医歯学総合病院, 医員 (20419328)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 骨粗鬆症 / 骨代謝マーカー / 歯槽骨生検 / 骨形態計測 / マイクロ CT / マイクロCT |
|---|
| Research Abstract |
Alveolar bone biopsy samples were extracted during implant preparation, for investigating microstructural changes due to menopause, and relationships between these changes and bone turnover markers. Subjects were 18 women receiving mandibular implants: premenopausal (n = 5), early postmenopausal (n = 3), and late postmenopausal (n = 10). The samples analyzed using micro-computed tomography and three-dimensional bone morphometry. The alveolar bone volume was significantly less in late postmenopausal women than in premenopausal ones. The trabeculae in early postmenopausal women were more separated and rod-like than in premenopausal ones. Each alveolar bone parameter was significantly related to at least one bone turnover marker. Alveolar cancellous bone structure begins changing even in early postmenopausal women, and this structure varies in close relationship to bone turnover markers.
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