Establishment of an early osteoporosis detection method using alveolar bone biopsy

Research Project

Project/Area Number	23890061
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Prosthetic dentistry
Research Institution	Niigata University
Principal Investigator	MIKAMI Emi 新潟大学, 医歯学総合病院, 医員 (20419328)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	骨粗鬆症 / 骨代謝マーカー / 歯槽骨生検 / 骨形態計測 / マイクロ CT / マイクロCT
Research Abstract	Alveolar bone biopsy samples were extracted during implant preparation, for investigating microstructural changes due to menopause, and relationships between these changes and bone turnover markers. Subjects were 18 women receiving mandibular implants: premenopausal (n = 5), early postmenopausal (n = 3), and late postmenopausal (n = 10). The samples analyzed using micro-computed tomography and three-dimensional bone morphometry. The alveolar bone volume was significantly less in late postmenopausal women than in premenopausal ones. The trabeculae in early postmenopausal women were more separated and rod-like than in premenopausal ones. Each alveolar bone parameter was significantly related to at least one bone turnover marker. Alveolar cancellous bone structure begins changing even in early postmenopausal women, and this structure varies in close relationship to bone turnover markers.