Molecular biological factors in drug-induced gingival overgrowth

• Project/Area Number: 23890063
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: SHIMIZU Taro 新潟大学, 医歯学総合病院, 医員 (60609121)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 歯肉増殖症 / 歯肉溝浸出液 / マルチプレックスサスペンションアレイ / マルチプレックスサスペンションシステム / タンパク質

Research Abstract

Gingival clevicular fluid (GCF) was extracted from gingival overgrowth sites and analyzed using a Multiplex suspension array system. A number of specifically expressed cellular growth factors, cell attachment factors, and inflammatory cytokines were examined from GO sites. The results showed significantly up-regulated levels of IL-8, as well as elevated levels of IL-1 beta,TGF-beta, and VEGF-A. Those results were reported at the American Academy of Periodontology.

Research Products

• [Journal Article] Gene and protein localisation of tumour necrosis factor (TNF)-α converting enzyme in gingival tissues from periodontitis patients with drug-induced gingival overgrowth (2013)
  • Author(s): Tomita T, Kubota T, Nakasone N, Morozumi T, Abe D, Maruyama S, Shimizu T, Horimizu M, Saku T, Yoshie H
  • Journal Title: Arch Oral Biol
• [Presentation] Molecular biological factors in drug-induced gingival overgrowth (2012)
  • Author(s): Shimizu T, Kubota T, Iwasaki M, Morozumi T, Nakasone N, Yoshie H
  • Organizer: 第98回 American Academy of Periodontology
  • Place of Presentation: Los Angeles, U. S. A
• [Presentation] Molecular biological factors in drug-induced ginigval overgrowth (2012)
  • Author(s): Taro Shimizu
  • Organizer: 第98回American Academy of Periodontology
  • Place of Presentation: LosAngeles Convention Center