Novel therapeutic method for drug addiction

• Project/Area Number: 23890076
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Applied pharmacology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: MURAKAMI Gen 浜松医科大学, 医学部, 特任研究員 (70613727)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: MHC / コカイン / 自己投与 / ドーパミン / 依存

Research Abstract

Using a novel system for drug self-administration with functional MHCI deficient mice, we revealed that reduction of MHCI is critically involved in the development of drug addiction

Research Products

• [Journal Article] Hunter R, Murakami G, Dewell S, Seligsohn M, Baker M, Datson N, McEwen BS, Pfaff D (2012)
  • Author(s): Hunter R, Murakami G, Dewell S, Seligsohn M, Baker M, Datson N, McEwen BS, Pfaff D
  • Journal Title: PNAS Volume: 109 Pages: 10657-62
• [Journal Article] Modulation of synaptic plasticity in the hippocampus by hippocampus-derived estrogen and androgen. (2012)
  • Author(s): Ooishi Y, Kawato S, Hojo Y, Hatanaka Y, Higo S, Murakami G, Komatsuzaki Y, Ogiue-Ikeda M, Kimoto T, Mukai H.
  • Journal Title: J Steroid Biochem Mol Biol. Volume: 131 Pages: 37-51
• [Journal Article] Corticosterone Induces Rapid Spinogenesis via Synaptic Glucocorticoid Receptors and Kinase Networks in Hippocampus. (2012)
  • Author(s): Komatsuzaki Y, Hatanaka Y, Murakami G, Mukai H, Hojo Y, Saito M, Kimoto T, Kawato S
  • Journal Title: PLoS One Volume: 7
• [Journal Article] Estradiol Rapidly Rescues Synaptic Transmission from Corticosterone-induced Suppression via Synaptic/Extranuclear Steroid Receptors in the Hippocampus (2011)
  • Author(s): Ooishi Y, Mukai H, Hojo Y, Murakami G, Hasegawa Y, Shindo T, Morrison JH, Kimoto T, Kawato S
  • Journal Title: Cereb Cortex Volume: 22 Pages: 926-36
• [Journal Article] Endogenous synthesis of corticosteroids in the hippocampus (2011)
  • Author(s): Higo S, Hojo Y, Ishii H, Komatsuzaki Y, Ooishi Y, Murakami G, Mukai H, Yamazaki T, Nakahara D, Barron A, Kimoto T, Kawato S.
  • Journal Title: PLoS One Volume: 6
  • NAID: 120005300503
• [Journal Article] Automated analysis of spines from confocal laser microscopy images: application to the discrimination of androgen and estrogen effects on spinogenesis (2011)
  • Author(s): Mukai H, Hatanaka Y, Mitsuhashi K, Hojo Y, Komatsuzaki Y, Sato R, Murakami G, Kimoto T, Kawato S
  • Journal Title: Cereb Cortex Volume: 21 Pages: 2704-11
• [Journal Article] Murakami G, Ribeiro A, Fontaine C, Hunter R, Pfaff D (2011)
  • Author(s): Murakami G, Ribeiro A, Fontaine C, Hunter R, Pfaff D
  • Journal Title: Eur J Neurosci Volume: 34 Pages: 469-77
• [Journal Article] Effects of Chronic Social Defeat on Physiology and Behavior; Vasopressin, Oxytocin and the Vasopressinergic V1b Receptor (2011)
  • Author(s): Litvin Y, Murakami G, Pfaff D
  • Journal Title: Physiol Behav. Volume: 103 Pages: 393-403
• [Presentation] Enhanced cocaine self administration in functional mhc class Ι deficient mice (2012)
  • Author(s): Murakami G, MENG H, Edamura M, Nakahara D.
  • Organizer: Society for neuroscience
  • Place of Presentation: New Orleans
• [Presentation] Enhanced cocaine self administration in functional mhc class Ι deficient mice (2012)
  • Author(s): 村上元
  • Organizer: Society for neuroscience
  • Place of Presentation: New Oleans