Bone regeneration with conditioned media from mesenchymal stem cells

• Project/Area Number: 23890079
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Kyoto University
• Principal Investigator: IKENO Masayuki 京都大学, 大学院・医学研究科, 医員 (70614486)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 幹細胞 / 培養上清 / 骨造成 / 頭頂骨 / ウサギ / チタン円筒 / 凍結乾燥粉末

Research Abstract

Conditioning media from mesenchymal stem cells of human bone marrow and deciduous teeth had many kinds of growth factors. It had enhanced bone regeneration on the augmentation model in rabbit. Moreover, freeze-dried powders of the conditioned media also had enhanced bone regeneration. It suggested the possibility of bone regeneration without cell treatment.

Research Products

• [Journal Article] Effects of the permeability of shields with autologous bone grafts on bone augmentation (2011)
  • Author(s): Ikeno M, Hibi H, Kinoshita K, Hattori H, Ueda M
  • Journal Title: Oral Craniofac Tissue Eng Volume: 1 Pages: 198-204
  • Peer Reviewed
• [Journal Article] Effects of the permeability of shields with autologous bone grafts on bone augmentation (2011)
  • Author(s): Ikeno M
  • Journal Title: Oral and Craniofacial Tissue Engineering Volume: 1 Pages: 198-204
  • Peer Reviewed
• [Journal Article] Rat bone marrow stromal cell-conditioned medium promotes early osseointegration of titanium implants
  • Author(s): Tsuchiya T, Hara K, Ikeno M, Okamoto Y, Hibi H, Ueda M
  • Journal Title: Int. J. Oral Maxillofac. Implants
  • Peer Reviewed
• [Presentation] 骨髄間質細胞由来の培養上清由来成長因子を付着させた骨再生誘導膜有用性の検討 (2012)
  • Author(s): 原憲治、土屋周平、池野正幸、日比英晴、上田実
  • Organizer: 第11回日本再生医療学会
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-13
• [Presentation] 骨髄間質細胞由来の培養上清由来成長因子を付着させた骨再生誘導膜有用性の検討 (2012)
  • Author(s): 原憲史
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: 横浜