The study of TGFβ associated novel biomarker that could detect high risk premalignant lesion.

• Project/Area Number: 23890080
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Nagoya University
• Principal Investigator: HAGIWARA Sumitaka 名古屋大学, 医学部附属病院, 医員 (40547551)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 口腔癌 / 前癌病変 / CD109 / 免疫組織化学 / 診断マーカー

Research Abstract

Immunohistochemical analysis using paraffin embedded samples of oral dyisplasia showed CD109 positive rate of high-risk group was significantly higher than that of control group. In immunohistochemical analysis of tongue squamous cell carcinoma (TSCC), a positive relation was existed between Ki-67 and CD109 expression in well or moderately differentiated TSCC including CIS.

Research Products

• [Journal Article] Pathological analysis of Ki-67 and CD109 expression in tongue squamous cell carcinoma (2013)
  • Author(s): Hagiwara S, Yamamoto N, Furue H, Sakakura H, Shigetomi T, Murakumo Y, Hibi H, Takahashi M, Ueda M
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Volume: 25 Issue: 3 Pages: 276-287
  • DOI: 10.1016/j.ajoms.2012.10.002
  • Peer Reviewed
• [Journal Article] Pathological analysis of Ki-67 and CD109 expression in tongue squamous cell carcinoma' (2012)
  • Author(s): Sumitaka Hagiwara, Noriyuki Yamamoto, Hiroki Furue, Hiroki Sakakura, Toshio Shigetomi, Yoshiki Murakumo, Hideharu Hibi, Masahide Takahashi, Minoru Ueda.
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Volume: Accepted 3
  • URL: http://dx.doi.org/10.1016/j.ajoms.2012.10.002
  • Peer Reviewed
• [Presentation] 口腔扁平上皮癌における CD109 の発現～新規腫瘍マーカーとしての有用性の検討～ (2012)
  • Author(s): 萩原純孝、山本憲幸、古江浩樹、坂倉寛紀、西川雅也、日比英晴、高橋雅英、上田実
  • Organizer: 第57回日本口腔外科学会総会・学術大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 口腔扁平上皮癌におけるCD109の発現～新規腫瘍マーカーとしての有用性の検討～ (2012)
  • Author(s): 萩原純孝
  • Organizer: 日本口腔外科学会総会・学術大会
  • Place of Presentation: 横浜
• [Presentation] ハイリスク異形上皮の臨床病理学的検討～病理組織像は癌化の可能性を反映するのか?～ (2011)
  • Author(s): 萩原純孝、山本憲幸、古江浩樹、和田垣龍、玉利正之、坂倉寛紀、澤村昌嗣、重冨俊雄、上田実
  • Organizer: 第56回日本口腔外科学会総会・学術大会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 口腔白板症の臨床病理学的検討～ハイリスク白板症の早期診断に向けて～ (2011)
  • Author(s): 萩原純孝、山本憲幸、古江浩樹、松本行史、佐藤文仁、和田垣龍、玉利正之、坂倉寛紀、澤村昌嗣、重冨俊雄、上田実
  • Organizer: 第65回日本口腔科学会学術集会
  • Place of Presentation: 東京:タワーホール船堀
• [Presentation] ハイリスク異形上皮の臨床病理学的検討～病理組織像は癌化の可能性を反映するのか？～ (2011)
  • Author(s): 萩原純孝
  • Organizer: 第56回日本口腔外科学会総会・学術大会
  • Place of Presentation: 大阪国際会議場（大阪）