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Analysis and risk assessment of intestinal inflammation induced by food-containing nanoparticles.

Research Project

Project/Area Number 23890082
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionMie University

Principal Investigator

OIKAWA Saeko (TADA Saeko)  三重大学, 地域イノベーション学研究科, 特任助教 (90610585)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsナノ粒子 / 二酸化チタン / 酸化亜鉛 / 炎症 / 二酸化ケイ素 / 大腸炎 / 腸管免疫機構 / 炎症性腸疾患
Research Abstract

The present study investigated the cytotoxicity, production of reactive oxygen species (ROS) and inflammatory cytokine induced by nano-TiO2 and nano-ZnO particles using human monocytic leukemia cells (THP-1) and human colon cancer cells (Caco-2). The viability of THP-1 macrophages exposed to nano-ZnO was lower than that to nano-TiO2 THP-1. The production of ROS and IL-1βshowed a tendency to be increased by nano-TiO2 particles. This study indicated that nano-TiO2 particles may induce inflammation in THP-1 macrophages through production of ROS and IL-1β, and nano- ZnO particles were suggested to be more toxic to THP-1 macrophages than nano-TiO_2 .

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (36 results)

All 2013 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (33 results)

  • [Journal Article] Serial changes in adipocytokines and cardiac function in a rat model of the metabolic syndrome2013

    • Author(s)
      Yamaguchi T, Kitamori K, Ichihara G, Suzuki Y, Ochiai M, Yamada Y, Tada-Oikawa S, Tsuchikura S, Yamori Y, Ichihara S
    • Journal Title

      Clinical and Experimental Pharmacology and Physiology

      Volume: (印刷中)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serial changes in adipocytokines and cardiac function in a rat model of the metabolic syndrome2013

    • Author(s)
      Takanori Yamaguchi
    • Journal Title

      Clinical and Experimental Pharmacology and Physiology

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat.2012

    • Author(s)
      Chang J, Oikawa S, Ichihara G, Nanpei Y, Hotta Y, Yamada Y, Tada-Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Ichihara S.
    • Journal Title

      Nutr Metab (Lond).

      Volume: 9(1) Issue: 1 Pages: 87-87

    • DOI

      10.1186/1743-7075-9-87

    • NAID

      120006667439

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] ナノ酸化亜鉛によるマクロファージの変性LDL取り込み作用への影響2013

    • Author(s)
      及川(多田)佐枝子、鈴木悠加、出岡淑、市原学、市原佐保子
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      2013-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] ナノ酸化亜鉛による血管内皮障害への影響2013

    • Author(s)
      鈴木悠加、及川(多田)佐枝子、出岡淑、市原学、市原佐保子
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      2013-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] ナノ酸化亜鉛が、ブレオマイシンによって誘導されるマウスの肺線維症に与える影響2013

    • Author(s)
      呉〓〓、市原学、及川(多田)佐枝子、鈴木悠加、常杰、橋本直純、長谷川好規、ガバザコリナ、ガバザエステバン、市原佐保子
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Year and Date
      2013-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Zinc oxide particles induced migration of monocytes and increased macrophage cholesterol uptake2013

    • Author(s)
      Yuka Suzuki, Saeko Tada-Oikawa, Gaku Ichihara, Sahoko Ichihara
    • Organizer
      52th Annual Meeting SOCIETY OF TOXICOLOGY
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2013-03-13
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] ナノ酸化亜鉛による単球遊走作用とマクロファージのコレステロール取り込み作用への影響2013

    • Author(s)
      鈴木悠加、及川(多田)佐枝子、出岡淑、市原学、市原佐保子
    • Organizer
      第12回分子予防環境医学研究会
    • Place of Presentation
      筑波
    • Year and Date
      2013-02-01
    • Related Report
      2012 Final Research Report
  • [Presentation] The effects of metal oxide nanoparticles on angiogenesis in transgenic zebrafish2013

    • Author(s)
      常杰、市原学、及川(多田)佐枝子、島田康人、田中利男、市原佐保子
    • Organizer
      第12回分子予防環境医学研究会
    • Place of Presentation
      筑波
    • Year and Date
      2013-02-01
    • Related Report
      2012 Final Research Report
  • [Presentation] ナノ酸化亜鉛による単球遊走作用とマクロファージのコレステロール取り込み作用への影響2013

    • Author(s)
      鈴木 悠加
    • Organizer
      第12回分子予防環境医学研究会
    • Place of Presentation
      つくばサイエンス・インフォメーションセンター (筑波市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The effects of metal oxide nanoparticles on angiogenesis in transgenic zebrafish.2013

    • Author(s)
      常 杰
    • Organizer
      第12回分子予防環境医学研究会
    • Place of Presentation
      つくばサイエンス・インフォメーションセンター (筑波市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノ酸化亜鉛によるマクロファージの変性LDL取り込み作用への影響2013

    • Author(s)
      及川(多田)佐枝子
    • Organizer
      第83回 日本衛生学会学術総会
    • Place of Presentation
      金沢大学、金沢美術工芸大学(石川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノ酸化亜鉛による血管内皮障害への影響2013

    • Author(s)
      鈴木 悠加
    • Organizer
      第83回 日本衛生学会学術総会
    • Place of Presentation
      金沢大学、金沢美術工芸大学(石川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノ酸化亜鉛が、ブレオマイシンによって誘導されるマウスの肺線維症に与える影響2013

    • Author(s)
      呉 文亭
    • Organizer
      第83回 日本衛生学会学術総会
    • Place of Presentation
      金沢大学、金沢美術工芸大学(石川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ゼブラフィッシュを用いたナノ酸化金属の血管新生に対する影響の検討2013

    • Author(s)
      常 杰
    • Organizer
      第83回 日本衛生学会学術総会
    • Place of Presentation
      金沢大学、金沢美術工芸大学(石川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dispersion method for safety research on manufactured nanomaterials2012

    • Author(s)
      Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, Sahoko Ichihara
    • Organizer
      第40回産業中毒・生物学的モニタリング研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Cytotoxicity and inflammatory responses induced by nano-sized metal oxide nanoparticles in human monocytic leukemia cells2012

    • Author(s)
      Saeko Tada-Oikawa, Masayuki Yabata, Kiyora Izuoka, Jie Chang, Yuka Ota, Wenting Wu, Sahoko Ichihara, Gake Ichihara
    • Organizer
      International Congress on Safety of Engineered Nanoparticles and Nanotechnologies
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2012-10-29
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Dispersion Method for Safety Researches on Manufactured Nanomaterials2012

    • Author(s)
      Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, Sahoko Ichihara
    • Organizer
      International Union of Materials Research societies-International Union of Materials Research societies-International Conference on Electronic Materials 2012
    • Place of Presentation
      Yokohama
    • Year and Date
      2012-09-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Cytotoxicity induced by nano-sized titanium dioxide in human monocytic leukemia cells (THP-1)2012

    • Author(s)
      Saeko Tada-Oikawa, Sahoko Ichihara,, Kiyora Izuoka,, Masayuki Yabata, Jie Chang, Yuka Ota, Wenting Wu, Gaku Ichihara
    • Organizer
      International Union of Materials Research societies-International Conference on Electronic Materials 2012
    • Place of Presentation
      Yokohama
    • Year and Date
      2012-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Cytotoxicity and inflammatory responses induced by nano-sized metal oxide nanoparticles in human monocytic leukemia cells2012

    • Author(s)
      Sahoko Ichihara, Saeko Tada-Oikawa, Masayuki Yabata, Kiyora Izuoka, Jie Chang, Yuka Ota, Wenting Wu, Gaku Ichihara
    • Organizer
      The 6th International Conference on Nanotoxicology
    • Place of Presentation
      Beijing, China
    • Year and Date
      2012-09-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Dispersion method for safety research on manufactured nanomaterials2012

    • Author(s)
      Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, Sahoko Ichihara
    • Organizer
      The 6th International Conference on Nanotoxicology
    • Place of Presentation
      Beijing, China
    • Year and Date
      2012-09-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Dispersion method for in vivo safety reseaches on manufactured nanomaterials2012

    • Author(s)
      Wenting Wu, Sahoko Ichihara, Saeko Tada-Oikawa, Jie Chang, Gaku Ichihara
    • Organizer
      The 6th International Congress of Asia Society of Toxicology
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2012-07-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Oxidative modification leads to the left ventricular dysfunction in cardiomyopathy2012

    • Author(s)
      Sahoko Ichihara, Jie Chang, Saeko Tada-Oikawa, Chisa Ando, Kentaro Kuzuya, Gaku Ichihara, Shinji Oikawa
    • Organizer
      The 49th Congress of the European Societies of Toxicology
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2012-06-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 二酸化チタンナノ粒子による細胞毒性作用および炎症反応誘導作用の解析2012

    • Author(s)
      及川(多田)佐枝子、呉〓〓、市原学 、常杰 、矢端将行 、及川伸二、市原佐保子
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-05-31
    • Related Report
      2012 Final Research Report
  • [Presentation] 工業ナノマテリアル安全性研究のための分散法2012

    • Author(s)
      呉〓〓、市原佐保子、常杰、及川(多田)佐枝子、太田有香、矢端将行、市原学
    • Organizer
      第85回日本産業衛生学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-05-31
    • Related Report
      2012 Final Research Report
  • [Presentation] 二酸化チタンナノ粒子による細胞毒性作用の解析2012

    • Author(s)
      及川(多田)佐枝子
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都市
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心筋症における左室機能不全に関与するタンパク質の酸化的修飾の検討2012

    • Author(s)
      市原佐保子
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都市
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 二酸化チタンナノ粒子による細胞毒性作用および炎症反応誘導作用の解析2012

    • Author(s)
      及川(多田)佐枝子
    • Organizer
      第85回 日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 工業ナノマテリアル安全性研究のための分散法2012

    • Author(s)
      呉 文亭
    • Organizer
      第85回 日本産業衛生学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Oxidative modification leads to the left ventricular dysfunction in cardiomyopathy2012

    • Author(s)
      Sahoko Ichihara
    • Organizer
      The 49th Congress of the European Societies of Toxicology
    • Place of Presentation
      Stockholm Waterfront Congress Centre (Stockholm, Sweden)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dispersion method for in vivo safety reseaches on manufactured nanomaterials2012

    • Author(s)
      Wenting Wu
    • Organizer
      The 6th International Congress of Asia Society of Toxicology,
    • Place of Presentation
      Sendai International Center(Sendai, Japan)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cytotoxicity and inflammatory responses induced by nano-sized metal oxide nanoparticles in human monocytic leukemia cells2012

    • Author(s)
      Sahoko Ichihara
    • Organizer
      6th International Conference on Nanotoxicology
    • Place of Presentation
      Beijing Friendship Hotel(China)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cytotoxicity induced by nano-sized titanium dioxide in human monocytic leukemia cells (THP-1)2012

    • Author(s)
      Saeko Tada-Oikawa
    • Organizer
      IUMRS-International Conference on Electronic Materials
    • Place of Presentation
      Pacifico Yokohama(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] DispersionMethod for Safety Researches onManufactured Nanomaterials2012

    • Author(s)
      Wenting Wu
    • Organizer
      IUMRS-International Conference on Electronic Materials
    • Place of Presentation
      Pacifico Yokohama(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dispersion method for safety research on manufactured nanomaterials.2012

    • Author(s)
      Wenting Wu
    • Organizer
      第40回産業中毒・生物学的モニタリング研究会
    • Place of Presentation
      ホテル マホロバ・マインズ三浦
    • Related Report
      2012 Annual Research Report
  • [Presentation] 抗がん性抗生物質アクラルビシンによる酸化的DNA損傷機構2011

    • Author(s)
      水谷秀樹
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2011
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-11-23
    • Related Report
      2011 Annual Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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