Role of PD-1 in Mycobacterium tuberculosis infection
Project/Area Number |
23890087
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Bacteriology (including Mycology)
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Research Institution | Kyoto University |
Principal Investigator |
SAKAI Shunsuke 京都大学, 大学院・医学研究科, 研究員 (50609063)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 細菌学 / 感染症 / 免疫学 |
Research Abstract |
CD4 T cell-mediated immune response is essential for the control of M. tuberculosis (Mtb) infection. Recent studies of the programmed cell death 1 (PD-1) receptor have provided novel insights into the inhibition of T-cell activation in infectious diseases. To clarify the role of PD-1 in Mtb infection, I investigated the course of Mtb infection in PD-1 KO mice. After infection, PD-1 KO mice die rapidly owing to severe lung damage. PD-1 KO mice developed higher numbers of IFN-γ-producing CD4 T cells compared to control mice. By using adoptive transfer and antibody blockade experiments, PD-1 deficiency in CD4 T cells and IFN-γ production by CD4 T cells aresufficient to cause the increased susceptibility to infection. These data show that PD-1 is essential in limiting CD4 T cell-mediated pathology in Mtb infection.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Del Carmen Sasiain M. Two genetically-related multidrug-resistant Mycobacterium tuberculosis strains induce divergent outcomes of infection in two human macrophage models2013
Author(s)
Yokobori N, Lopez B, Geffner L, Sabio Y Garcia C, Schierloh P, Barrera L, de la Barrera S, Sakai S, Kawamura I, Mitsuyama M, Ritacco V
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Journal Title
Infect Genet Evol.
Volume: 16
Pages: 151-156
DOI
Related Report
Peer Reviewed
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[Journal Article] Critical roles of ASC in flammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.2011
Author(s)
R. Fang, K. Tsuchiya, I. Kawamura, Y. Shen, H. Hara, S. Sakai, T. Yamamoto, T. Fernandes-Alnemri, R. Yang, E. Hernandez-Cuellar, S. R. Dewamitta, Y. Xu, H. Qu, E. S. Alnemri, and M. Mitsuyama
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Journal Title
J. Immunol
Volume: 187
Issue: 9
Pages: 4890-4899
DOI
Related Report
Peer Reviewed
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[Journal Article] Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces lowtumour necrosis factor alpha and interleukin 6 production in murine macrophages.2011
Author(s)
S. Daim, T. Nomura, I. Kawamura, H. Hara, K. Tsuchiya, T. Kurenuma, Y. Shen, T. Yamamoto, H. Qu, S. Sakai, Y. Xu, and M. Mitsuyama.
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Journal Title
J. Med. Microbiol
Volume: 60
Issue: 5
Pages: 582-591
DOI
Related Report
Peer Reviewed
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