Research Project
Grant-in-Aid for Research Activity Start-up
Bone marrow samples from ALL patients were transplanted into NOG mouse and extramedullary organs including CNS showed the leukemic invasion. In the CNS, we observed the infiltration of leukemic cells that is consistent with pathology of human ALL patients. Several analyses suggest that our model recapitulates the CNS disease and histopathology of human ALL leukemic CNS. To identify genes involved in CNS leukemia development, we applied high-density oligonucleotide arrays to leukemic cells in CNS and BM. A series of CNS leukemic cell-specific gene sets have been successfully identified. Next, we transplanted leukemic cells harvested from CNS into NOG mice, and leukemic cells reconstitute the leukemia. Those results showed that leukemic cells in CNS contributed to the relapse of the disease with altering the gene expressionpattern. This information could be utilized for further mechanistic research and for devising optimized therapeutic strategies against CNS leukemia.
All 2013 2012 2011 Other
All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (11 results) (of which Invited: 2 results) Book (1 results) Remarks (2 results)
Blood
Volume: 121 Issue: 21 Pages: 4377-4387
10.1182/blood-2012-12-474387
PLos one
Volume: 6 Issue: 11 Pages: e27042-e27042
10.1371/journal.pone.0027042
http://www.kuhp.kyoto-u.ac.jp/~pediatrics/
