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Overcoming the resistance to molecular-targeted therapy for renalcell carcinoma by analyzing of VHL control mechanism in a HIF independent manner

Research Project

Project/Area Number 23890093
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionKyoto University

Principal Investigator

YAMASAKI Toshinari  京都大学, 大学院・医学研究科, 助教 (00607749)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腎細胞癌 / 抗血管新生療法 / VHL / CCL2 / JunB / EphriaB2
Research Abstract

We previously reported that the pathway of pVHL-atypical PKC-JunB in a hypoxia-inducible factor (HIF) independent manner contributed to the progression in clear cell renal cell carcinoma (ccRCC), and detected chemokine (C-C motif) ligand-2 (CCL2) as one of a downstream effector of it. To obtain findings of overcoming resistance to existing anti-VEGF therapies, the purpose of this research is to investigate the utility of CCL2 as a novel therapeutic target in ccRCC. In this study, we evaluated CCL2 expression in ccRCC clinical specimens, and confirmed that CCL2 expression involved in tumor growthand vascularization in xenograft derived from ccRCC cell lines. Moreover, we confirmed the anti-tumor effect of CCL2 neutralization antibodies to xenograft derived from ccRCC clinical specimens and cell lines. These results suggest that CCL2 could be a potential therapeutic target in ccRCC.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (4 results)

All 2013 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy2012

    • Author(s)
      Yamasaki, et al
    • Journal Title

      Cancer Science

      Volume: 103(11) Issue: 11 Pages: 2027-37

    • DOI

      10.1111/j.1349-7006.2012.02412.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 腎細胞癌に対する新規治療ターゲットとしての CCL2 の検討2013

    • Author(s)
      新垣、山崎ほか
    • Organizer
      第22回泌尿器科分子・細胞研究会
    • Place of Presentation
      高知
    • Year and Date
      2013-03-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎細胞癌に対する新規治療ターゲットとしてのCCL2の検討

    • Author(s)
      新垣隆一郎(山崎俊成)
    • Organizer
      第22回泌尿器科分子・細胞研究会
    • Place of Presentation
      高知
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.urology.kuhp.kyoto-u.ac.jp/

    • Related Report
      2012 Final Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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