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Analysis of epigenetics induced by Interleukin 6

Research Project

Project/Area Number 23890098
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionOsaka University

Principal Investigator

ISOBE Tomoyasu  大阪大学, 大学院・工学研究科, 特任助教 (40402341)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords炎症 / エピジェネティクス / 転写制御
Research Abstract

In chronic inflammation disease, constitutively produced inflammatory cytokines perturb various gene expression mechanisms. We focused on epigenetic regulation of gene expression, and found several modifications on histone which were specifically altered by IL-6. On the other hand, we proposed a novel model which could explain aberrant regulation of epigenetics in inflammatory-associated cancer.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (5 results)

All 2013 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Prediction and experimental validation of putative non-consensus binding site for transcription factor STAT3 in Serum amyloid A gene promoter.2013

    • Author(s)
      Tiwari, P., Tripathi, LP., Nishikawa-Matsumura, T., Ahmad, S., Soken-Nakazawa, J-S., Isobe, T., Mizuguchi, K. and Yoshizaki, K.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1830 Pages: 3650-3655

    • Related Report
      2012 Final Research Report
  • [Journal Article] Prediction and experimental validation of putative non-consensus binding site for transcription factor STAT3 in Serum amyloid A gene promoter2013

    • Author(s)
      Tiwari, P., Tripathi, LP., Nishikawa-Matsumura, T., Ahmad, S., Song, SN., Isobe. T., Mizuguchi, K., Yoshizaki, K
    • Journal Title

      Blochim Biophys Acta

      Volume: (印刷中)(掲載確定)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression.

    • Author(s)
      Isobe, T., Soken-Nakazawa, J-S., Tiwari, P., Ito, H., Yamaguchi Y. and Yoshizaki, K.
    • Journal Title

      FEBS Lett

      Volume: (in press)

    • Related Report
      2012 Final Research Report
  • [Presentation] 炎症性サイトカインによる急性期タンパク質(CRP,SAA)の発現機序2011

    • Author(s)
      磯部智康
    • Organizer
      第32回日本炎症・再生学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-06-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Synergistic effect of IL-6 and IL-1/TNFalpha signaling on gene expression of C-Reactive Protein2011

    • Author(s)
      Tomoyasu Isobe
    • Organizer
      13^<th> international TNF conference
    • Place of Presentation
      淡路夢島国際会議場(兵庫県)
    • Year and Date
      2011-05-17
    • Related Report
      2011 Annual Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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