Analysis of epigenetics induced by Interleukin 6

• Project/Area Number: 23890098
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Osaka University
• Principal Investigator: ISOBE Tomoyasu 大阪大学, 大学院・工学研究科, 特任助教 (40402341)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 炎症 / エピジェネティクス / 転写制御

Research Abstract

In chronic inflammation disease, constitutively produced inflammatory cytokines perturb various gene expression mechanisms. We focused on epigenetic regulation of gene expression, and found several modifications on histone which were specifically altered by IL-6. On the other hand, we proposed a novel model which could explain aberrant regulation of epigenetics in inflammatory-associated cancer.

Research Products

• [Journal Article] Prediction and experimental validation of putative non-consensus binding site for transcription factor STAT3 in Serum amyloid A gene promoter. (2013)
  • Author(s): Tiwari, P., Tripathi, LP., Nishikawa-Matsumura, T., Ahmad, S., Soken-Nakazawa, J-S., Isobe, T., Mizuguchi, K. and Yoshizaki, K.
  • Journal Title: Biochim Biophys Acta Volume: 1830 Pages: 3650-3655
• [Journal Article] Prediction and experimental validation of putative non-consensus binding site for transcription factor STAT3 in Serum amyloid A gene promoter (2013)
  • Author(s): Tiwari, P., Tripathi, LP., Nishikawa-Matsumura, T., Ahmad, S., Song, SN., Isobe. T., Mizuguchi, K., Yoshizaki, K
  • Journal Title: Blochim Biophys Acta Volume: (印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression.
  • Author(s): Isobe, T., Soken-Nakazawa, J-S., Tiwari, P., Ito, H., Yamaguchi Y. and Yoshizaki, K.
  • Journal Title: FEBS Lett Volume: (in press)
• [Presentation] 炎症性サイトカインによる急性期タンパク質(CRP,SAA)の発現機序 (2011)
  • Author(s): 磯部智康
  • Organizer: 第32回日本炎症・再生学会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2011-06-03
• [Presentation] Synergistic effect of IL-6 and IL-1/TNFalpha signaling on gene expression of C-Reactive Protein (2011)
  • Author(s): Tomoyasu Isobe
  • Organizer: 13^<th> international TNF conference
  • Place of Presentation: 淡路夢島国際会議場(兵庫県)
  • Year and Date: 2011-05-17