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Anti-biofilm effects of azithromycin on Porphyromonas gingivalis

Research Project

Project/Area Number 23890103
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionOsaka University

Principal Investigator

MAEZONO Hazuki  大阪大学, 歯学部附属病院, 医員 (00613390)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsバイオフィルム / 抗生物質 / ポルフィロモナス / ジンジバリス / 歯学 / ポルフィロモナス ジンジバリス / ポルフィロモナス ジンジバリス
Research Abstract

Anti-biofilm effects of azithromycin (AZM) on Porphyromonas gingivaliswere investigated using modified Robbins device. We examined protein expressions of AZM-treated/non-treated Porphyromonas gingivalis and found that protein expressions of sub-MIC AZM treated planktonic and biofilm-detached cells were different at 50 and 110 kDa. Proteins were turned out to be glutamate dehydrogenase, hemagglutinin protein and RagA protein.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (14 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (10 results)

  • [Journal Article] Porphyromonas gingivalis biofilms persist after chlorhexidine treatment2013

    • Author(s)
      Yamaguchi M, Noiri Y, Kuboniwa M, Yamamoto R, Asahi Y, Maezono H, Hayashi M, Ebisu S
    • Journal Title

      Eur J Oral Sci

      Volume: Vol.121 Issue: 3pt1 Pages: 162-8

    • DOI

      10.1111/eos.12050

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The sinR ortholog PGN_0088 encodes a transcriptional regulator that inhibits polysaccharide synthesis in Porphyromonas gingivalis ATCC 33277 biofilms2013

    • Author(s)
      Yamamoto R, Noiri Y, Yamaguchi M, Asahi Y, Maezono H, Kuboniwa M, Hayashi M, Ebisu S
    • Journal Title

      PLoS One

      Volume: Vol.8, No.2 Issue: 2 Pages: e56017-e56017

    • DOI

      10.1371/journal.pone.0056017

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-biofilm effects of azithromycin and erythromycin on Porphyromonas gingivalis2011

    • Author(s)
      Maezono H, Noiri Y, Asahi Y, Yamaguchi M, Yamamoto R, Izutani N, Azakami H, Ebisu S
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 55 Issue: 12 Pages: 5887-5892

    • DOI

      10.1128/aac.05169-11

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time-course gene expression during Porphyromonas gingivalis strain ATCC 33277 biofilm formation2011

    • Author(s)
      Yamamoto R, Noiri Y, Yamaguchi M, Asahi Y, Maezono H, Ebisu S
    • Journal Title

      Appl Environ Microbiol

      Volume: 77 Issue: 18 Pages: 6733-6736

    • DOI

      10.1128/aem.00746-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Azithromycin alters protein expressions in Porphyromonas gingivalisbiofilm-detached cells2012

    • Author(s)
      H. MAEZONO, Y. NOIRI, Y. ASAHI, M. YAMAGUCHI, R. YAMAMOTO, M. HAYASHI and S. EBISU
    • Organizer
      第60回国際歯科研究学会日本部会(JADR)
    • Place of Presentation
      新潟県新潟市
    • Year and Date
      2012-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Altered protein expressions by sub-minimum inhibitory concentrations of azithromycin on Porphyromonas gingivalis biofilms2012

    • Author(s)
      H. MAEZONO, Y. NOIRI, Y. ASAHI, M. YAMAGUCHI, R. YAMAMOTO, K. KUREMOTO, M. HAYASHI and S. EBISU
    • Organizer
      ASM 6thconference on biofilms
    • Place of Presentation
      Miami, USA
    • Year and Date
      2012-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Porpbyromonas gingivalis PGN_0088遺伝子のバイオフィルム形成における役割2012

    • Author(s)
      山本れいこ, ら
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Sub-MICの緑茶カテキンがPorpbyromonas gingivalisバイオフィルムに及ぼす影響の検索2011

    • Author(s)
      朝日陽子, ら
    • Organizer
      第135回日本歯科保存学会秋季学術大会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Remnant matrix of Porphyromonas gingivalis biofilm treated with chlorhexidine2011

    • Author(s)
      Yamaguchi M, et al
    • Organizer
      International Union of Microbial Societies 2011 Congress
    • Place of Presentation
      Sapporo (Japan)
    • Year and Date
      2011-09-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Porphyromonas gingivalisのバイオフィルムに対するクロルヘキシジンの影響2011

    • Author(s)
      山口幹代, ら
    • Organizer
      第25回Bacterial Adherence & Biofilm
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Porphyromonas gingivalisバイオフィルムに対する各種抗菌薬の抗バイオフィルム効果2011

    • Author(s)
      前薗葉月、野杁由一郎、朝日陽子、山口幹代、山本れいこ、薮根敏晃、恵比須繁之
    • Organizer
      第134回日本歯科保存学会
    • Place of Presentation
      千葉県浦安市
    • Year and Date
      2011-06-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Porphyromonas gingivalisバイオフィルムに対する各種抗菌薬の抗バイオフィルム効果2011

    • Author(s)
      前薗葉月, ら
    • Organizer
      第134回日本歯科保存学会春季学術大会
    • Place of Presentation
      東京ベイ舞浜ホテルクラブリゾート(千葉)
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Altered protein expressions by sub-minimum inhibitory concentrations of azithromycin on Porphyromonas gingivalis biofilms

    • Author(s)
      Hazuki Maezono
    • Organizer
      ASM 6th Conference on Biofilms
    • Place of Presentation
      Miami, FL, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Azithromycin alters protein expressions in Porphyromonas gingivalis biofilm-detached cells

    • Author(s)
      Hazuki Maezono
    • Organizer
      第60回 国際歯科研究学会日本部会(JADR)総会・学術大会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Related Report
      2012 Annual Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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