An analysis of the enhancement mechanism of antitumor cytotoxic T cells by B7.2
| Project/Area Number |
23890106
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 腫瘍免疫 / 細胞障害性T細胞 / 悪性腫瘍 / 細胞傷害性T細胞 |
|---|
| Research Abstract |
We cultured spleen cells and B 7.2 of the cancer bearing mouse. As a result, we were able to induce CTL in a high ratio in a certain tumor. However, CTLA-4 was not associated with an induction mechanism of the CTL. It was suggested that stimulation to CD28 by B7．2 was a main pathway to CTL induction in our study. Also, we investigate the enhancement effect with the immunostimulation nutrient for enhancement of antitumor CTL.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] A case of malignant melanoma discovered as a result of metastatic disease of the temporomandibular joint.2013
Author(s)
YasunariMorimoto, Suguru Hamada,Takafumi,Ogura,HirokazuNakahara, Akifumi,Enomoto,Takayuki Uchihashi,Shin-ichiro Hiraoka,MIkihiko Kogo
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: Volume 25, Issue 1
Pages: 74-78
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Peer Reviewed
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[Journal Article]2012
Author(s)
浜口裕弘, 松岡裕大, 磯村恵美子, 永谷俊介,占部一彦, 川嵜康大, 西野仁, 平岡慎一郎, 鏡内 肇
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Journal Title
大阪大学歯学会雑誌
Volume: 56巻2号
Pages: 119-122
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Peer Reviewed
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[Presentation] 舌に生じた紡錐細胞癌の1例2011
Author(s)
平岡 慎一郎,伊藤 章,大倉 正也,古郷 幹彦,北村 龍二
Organizer
第35回日本頭頸部癌学会学術集会
Place of Presentation
愛知県名古屋市
Year and Date
2011-06-09
Related Report
