| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We cultured spleen cells and B 7.2 of the cancer bearing mouse. As a result, we were able to induce CTL in a high ratio in a certain tumor. However, CTLA-4 was not associated with an induction mechanism of the CTL. It was suggested that stimulation to CD28 by B7．2 was a main pathway to CTL induction in our study. Also, we investigate the enhancement effect with the immunostimulation nutrient for enhancement of antitumor CTL.
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