| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
PLAP-1 inhibited LPS-induced inflammation with mouse periodontal ligament cells(MPDL22). In addition, the D14 allele of PLAP-1 inhibited LPS-induced inflammation more strongly compared to the D13 allele of PLAP-1. However, there was no significant difference of LPS-induced inflammation between PLAP-1 deficient mice and wild type mice. Now, I try to make the mouse model of periodontal disease which can elucidate the correlation between polymorphism in PLAP-1 and periodontal inflammation with D13- and D14-PLAP-1 expressing adenovirus system.
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