Effects of polyols on periodontopathic biofilm development
Project/Area Number |
23890112
|
Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Social dentistry
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Research Institution | Osaka University |
Principal Investigator |
HASHINO Ei 大阪大学, 歯学部附属病院, 特任助教 (90614553)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 糖アルコール / 歯周病細菌 / バイオフィルム / メタボローム解析 / Porphyromonas gingivalis / Filifactor alocis / 歯周病原性バイオフィルム / プロテオーム解析 |
Research Abstract |
Our previous study showed that sugar alcohols(polyols) such as erythritol inhibited Streptococcus gordonii-Porphyromonas gingivalisbiofilm formation and erythritol was the most effective reagent to reduce P. gingivalisas compared with other tested polyols. To examine the inhibitory effects of erythritol, we analyzed the metabolomic profiles of erythritol-treated P. gingivalis and S. gordonii cells. These results suggest that erythritol has inhibitory effects on dual species biofilm development via several pathways, including suppression of growth resulting from DNA and RNA depletion and alteration of central carbon metabolism.
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Report
(3 results)
Research Products
(26 results)