A novel transcriptional pathway of chronic inflammation in metabolic syndrome

• Project/Area Number: 23890116
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Okayama University
• Principal Investigator: EGUCHI Jun 岡山大学, 岡山大学病院, 助教 (60616366)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: メタボリック症候群 / 慢性炎症 / メタボリックシンドローム / IRF4 / マクロファージ / インスリン抵抗性

Research Abstract

The enormous burden of metabolic disease in our society requires that we seek novel therapeutic strategies. Chronic inflammation inmetabolic syndrome leads to reduced systemic insulin sensitivity. In this study, we found that IRF4 is a negative regulator of inflammation in metabolic syndrome. IRF4 might be a novel therapeutic target for insulin resistance.

Research Products

• [Journal Article] FOSL2 promotes human adipocyte-specific leptin gene expression (2012)
  • Author(s): Wrann CD, Eguchi J, Bozec A, Xu Z, Mikkelsen T, Gimble J, Nave H, Wagner EF, Ong SE, Rosen ED
  • Journal Title: Journal Clin Invest Volume: 122 Pages: 1010-21
  • Peer Reviewed
• [Journal Article] RXR antagonism induces G(0)/G(1) cell cycle arrest and ameliorates obesity by up-regulating the p53-p21 pathway in adipocytes. (2012)
  • Author(s): Nakatsuka A, Wada J, Hida K, Hida A,Eguchi J, Teshigawara S, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Ogawa D, Kagechika H, Makino H
  • Journal Title: J Pathol Volume: 226 Pages: 784-95
  • Peer Reviewed
• [Journal Article] Serum vaspin concentrations are closely related to insulin resistance, and rs77060950 at serpina12 genetically defines distinct group with higher serum levels in japanese population. (2012)
  • Author(s): Teshigawara S, Wada J, Hida K, Nakatsuka A, Eguchi J,Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Iseda I, Matsushita Y, Miyatake N, McDonald JF, Hotta K, Makino H
  • Journal Title: J Clin Endocrinol Metab Volume: 97(7) Pages: 1202-7
  • NAID: 120005232486
  • Peer Reviewed
• [Journal Article] Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes. (2011)
  • Author(s): Kanzaki M, Wada J, Sugiyama K, Nakatsuka A, Teshigawara S, Murakami K, Inoue K, Terami T, Katayama A, Eguchi J,Makino H
  • Journal Title: Endocrinology Volume: 153(2) Pages: 612-20
  • Peer Reviewed
• [Presentation] レプチン遺伝子の発現を制御する新規転写因子の同定 (2012)
  • Author(s): 江口 潤
  • Organizer: 第33回日本肥満学会 シンポジウム「Adiposcienceの新展開 肥満症の基礎研究」
  • Place of Presentation: 京都
  • Year and Date: 2012-10-12
• [Presentation] 「Roles of IRF4 in adipocyte biology」シンポジウム (2011)
  • Author(s): 江口 潤
  • Organizer: 第34回日本分子生物学学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-15
• [Presentation] メタボリック症候群におけるIRF4の役割 (2011)
  • Author(s): 江口潤
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: パシフィコ横浜(招待講演)
  • Year and Date: 2011-12-15
• [Presentation] メタボリック症候群におけるマクロファージIRF4の役割 (2011)
  • Author(s): 江口 潤
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 兵庫県淡路市
  • Year and Date: 2011-09-24
• [Presentation] メタボリック症候群におけるマクロファージIRF4の役割 (2011)
  • Author(s): 江口潤
  • Organizer: 1.第32回日本肥満学会
  • Place of Presentation: 兵庫県淡路市
  • Year and Date: 2011-09-24
• [Presentation] メタボリック症候群におけるIRF4 の役割 (2011)
  • Author(s): 江口 潤
  • Organizer: 2011 年度アディポサイエンス研究会 (招待講演)
  • Place of Presentation: 大阪府豊中市
  • Year and Date: 2011-08-20
• [Presentation] メタボリック症候群におけるIRF4の役割 (2011)
  • Author(s): 江口潤
  • Organizer: 2011年度アディポサイエンス研究会
  • Place of Presentation: 大阪府豊中市(招待講演)
  • Year and Date: 2011-08-20
• [Presentation] メタボリック症候群におけるマクロファージIRF4の病態生理学的意義
  • Author(s): 江口 潤
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜市
• [Presentation] レプチン遺伝子の発現を制御する新規転写因子の同定
  • Author(s): 江口 潤
  • Organizer: 第33回日本肥満学会
  • Place of Presentation: 京都市
  • Invited