The functional analysis of WISP-1 gene in osteoarthritis and chondrogenic differentiation.
| Project/Area Number |
23890122
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
ONO Mitsuaki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60613156)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 軟骨分化 / WISP-1 / 変形性関節症 / 分泌タンパク質 / WISP-1タンパク質 |
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| Research Abstract |
The purpose of this study was to clarify the relationship between WISP-1 gene and osteoarthritis (OA). First, we analyzed the knee joint histologically, and OA like condition was observed in WISP-1 KO mice. Moreover, overexpression of WISP-1 enhanced the chondrogenic differentiation in human bone marrow stromal cells. These data show that WISP-1 could be involved in the onset of OA by regulating the chondrogenic differentiation.
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Report
(3 results)
Research Products
(8 results)
