The functional analysis of WISP-1 gene in osteoarthritis and chondrogenic differentiation.

• Project/Area Number: 23890122
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Okayama University
• Principal Investigator: ONO Mitsuaki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60613156)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 軟骨分化 / WISP-1 / 変形性関節症 / 分泌タンパク質 / WISP-1タンパク質

Research Abstract

The purpose of this study was to clarify the relationship between WISP-1 gene and osteoarthritis (OA). First, we analyzed the knee joint histologically, and OA like condition was observed in WISP-1 KO mice. Moreover, overexpression of WISP-1 enhanced the chondrogenic differentiation in human bone marrow stromal cells. These data show that WISP-1 could be involved in the onset of OA by regulating the chondrogenic differentiation.

Research Products

• [Presentation] WISP-1/CCN4 Regulates Osteogenic Differentiation by Controlling BMP-2 Function (2013)
  • Author(s): 大野充昭
  • Organizer: 2013 IADR Asia/Pacific Region
  • Place of Presentation: Bangkok, Thailand
• [Presentation] WISP-1/CCN4 Regulates Osteogenic Differentiation by Controlling BMP-2 Function in vitro and in vivo (2013)
  • Author(s): 大野充昭
  • Organizer: The 2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research.
  • Place of Presentation: Kobe, Japan
• [Presentation] CCN3/NOVの軟骨特異的過剰発現は軟骨分化の最終段階に影響を及ぼすことにより骨形成不全をきたす (2012)
  • Author(s): 服部高子,大野充昭
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-16
• [Presentation] 皮膚創傷治癒過程におけるCCN4/WISP-1遺伝子の役割 (2012)
  • Author(s): 正木明日香,大野充昭
  • Organizer: 第10回日本再生歯科医学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2012-09-02
• [Presentation] WISP-1/CCN4: Potential Regulation of Mineralized Tissue through Modulation of Wnt Signaling. (2012)
  • Author(s): Maeda A.Ono M
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-07-20
• [Presentation] WISP-1/CCN4: Potential Regulation of Mineralized Tissue through Modulation of Wnt Signaling (2012)
  • Author(s): Maeda A.Ono M
  • Organizer: National Institute of Dental and Craniofacial Research 6th Annual Fellows Retreat
  • Place of Presentation: Chamberland, USA
  • Year and Date: 2012-04-19
• [Presentation] Determiningthe function of WISP-1/CCN4 in mineralized tissue (2011)
  • Author(s): Maeda A.Ono M
  • Organizer: American Society for Bone and Mineral Research 2011Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-09-18
• [Presentation] Determiningthe function of WISP-1/CCN4 in mineralized tissue (2011)
  • Author(s): Maeda A.Ono M
  • Organizer: National Institute of Dental and Craniofacial Research 5th Annual Fellows Retreat
  • Place of Presentation: Chamberland, USA
  • Year and Date: 2011-04-14