Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Research Abstract |
The purpose of this study was to clarify the relationship between WISP-1 gene and osteoarthritis (OA). First, we analyzed the knee joint histologically, and OA like condition was observed in WISP-1 KO mice. Moreover, overexpression of WISP-1 enhanced the chondrogenic differentiation in human bone marrow stromal cells. These data show that WISP-1 could be involved in the onset of OA by regulating the chondrogenic differentiation.
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