Investigation of the mechanisms involving BMP-2-induced inhibition of bone formation or niche formation at the bone marrow microenvironment.
| Project/Area Number |
23890123
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
OIDA Yasutaka 岡山大学, 岡山大学病院, 医員 (50625720)
SONOYAMA Wataru 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40325121)
KUBOKI Takuo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00225195)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | BMP-2 / 骨髄 / 血球系細胞 |
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| Research Abstract |
BMP-2 is widely known as an osteogenic inducer, but conflicting results are related to its function inside the bone marrow space. This study aimed to clarify the molecular mechanisms and impact of BMP-2 on bone metabolism environment of the bone marrow space. Of great interest, we found that BMP-2 inhibits bone formation in bone marrow space. To date, in an attempt to elucidate this mechanism, we are focusing on BMP-2 negative feedback regulation as well as on cellular and molecular interactions from an immunological perspective.
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Report
(3 results)
Research Products
(8 results)
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[Patent(Industrial Property Rights)] 人工骨膜2011
Inventor(s)
窪木拓男,園山 亘,大野充昭,笈田育尚,山本克史,中尾 眞,森田 潔
Industrial Property Rights Holder
窪木拓男,園山 亘,大野充昭,笈田育尚,山本克史,中尾 眞,森田 潔
Industrial Property Number
2011-113498
Filing Date
2011-05-20
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