Investigation of the enhancement of periodontal regeneration by inhibition of gingival downgrowth by Smad2 overexpression

• Project/Area Number: 23890128
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Kyushu University (2012); Okayama University (2011)
• Principal Investigator: TOMIKAWA Kazuya 九州大学, 大学病院, 助教 (60614922)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 歯学 / 再生医学 / 細胞・組織 / マイクロアレイ / smad2 / 歯周組織再生療法 / 歯肉上皮 / ダウングロース / 歯周炎マウスモデル / Smad2 / 歯周炎モデル

Research Abstract

We made alveolar bone defect in mouse by the mechanical way to inhibit gingival downgrowth. But we modified the way to suit clinical situation. Finally, the mouse model was established by infection of periodontopathic bacteria, we could confirm a clear alveolar bone defect by CT scan. Additionally our findings indicated that healing of periodontal connective tissue was promoted in TG as compared with WT.

Research Products

• [Journal Article] Overexpression of Smad2 Inhibits Proliferation of Gingival Epithelial Cells (2013)
  • Author(s): Shimoe M, Yamamoto T, Shiomi N, Tomikawa K, Hongo S, Yamashiro K, Yamaguchi T, Maeda H, Takashiba S
  • Journal Title: J Periodontal Res
• [Journal Article] Smad2 Decelerates Re-epithelialization during Gingival Wound Healing (2012)
  • Author(s): Tomikawa K, Yamamoto T, Shiomi N, Shimoe M, Hongo S, Yamashiro K, Yamaguchi T, Maeda H, and Takashiba S.
  • Journal Title: J Dent Res Volume: 91(8) Pages: 764-70
  • Peer Reviewed
• [Journal Article] Smad2 decekerates re-epithelialization during gingival wound healing. (2012)
  • Author(s): Tomikawa Kazuya
  • Journal Title: journal of dentak research Volume: 91 Issue: 8 Pages: 764-770
  • DOI: 10.1177/0022034512451449
  • Peer Reviewed
• [Presentation] 歯肉上皮細胞において外因性Smad2 は細胞接着分子の発現を促進する (2011)
  • Author(s): 本郷昌一,山城圭介,山本直史,下江正幸,冨川和哉,鵜川祐樹,高知信介,塩見信行,前田博史,高柴正悟
  • Organizer: 第54回日本歯周病学会秋季学術大会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-14
• [Presentation] Smad2による歯肉創傷治癒の再上皮化抑制に関する研究 (2011)
  • Author(s): 冨川和哉
  • Organizer: 第53回春季日本歯周病学会学術大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2011-05-27
• [Presentation] Smad2による歯肉創傷治癒の再上皮化抑制 (2011)
  • Author(s): 冨川和哉,山本直史,下江正幸,塩見信行,峯柴淳二,山口知子,本郷昌一,前田博史,高柴正悟
  • Organizer: 53 巻日本歯周病学会会誌春季特別号