The molecular mechanism of Granulovacuolar degeneration in Alzheimer disease via ESCRT pathway

• Project/Area Number: 23890130
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Hiroshima University
• Principal Investigator: NAGANO Yoshito 広島大学, 大学院・医歯薬保健学研究院, 助教 (50397973)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ESCRT pathway / HDAC6 / アルツハイマー病 / 顆粒空胞変性 / ESCRTファミリー / ESCRT経路

Research Abstract

HDAC6 which is involved in protein aggregation and autophagy located in Granulovacuolar degeneration(GVD) in the brain of Alzheimer disease(AD). We found that the culture cells transfected with CHMP2B constructs would be the AD-model cell line. HDAC6 bound to CHMP2B and could regulate the acetylation level and function of CHMP2B.