Regulation of cytotoxic activity of liver NK cells against islet graft
| Project/Area Number |
23890132
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
ISHIYAMA Kohei 広島大学, 医歯薬保健学研究院, 特任助教 (50437589)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 膵島移植 / NK 細胞 / NK細胞 / 肝臓免疫 |
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| Research Abstract |
Islet transplantation becomes one of the therapeutic option for cure of type 1 diabetes. In this study, we have researched the possibility of regulation of natural killer cells cytotoxicity against transplanted islet graft. Co-culture with both prostaglandin E2 and TGF-beta can suppress the cytokine stimulated-NK cells cytotoxicity.
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Report
(3 results)
Research Products
(14 results)
