A study for the application of inorganic polyphosphate in peri-implantitis treatment
| Project/Area Number |
23890134
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
HARADA Kana 広島大学, 大学院・医歯薬保健学研究院, 特任助教 (90609744)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ポリリン酸 / マクロファージ / 炎症 / インプラント |
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| Research Abstract |
Inorganic polyphosphate [poly(P)], a linear polymer of orthophosphate residues, has antibacterial effects against Porphyromonas gingivalis and promotes tissue regeneration and bone formation. In this study, I examined effects of poly(P) in macrophages for the application of poly(P) in peri-implantitis treatment, and found that poly(P) suppresses the expression of inducible nitric oxide synthase and the release of nitric oxide in macrophages stimulated by lipopolysaccharide, a cell wall component of Gram-negative bacteria.
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Report
(3 results)
Research Products
(12 results)
