| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Inorganic polyphosphate [poly(P)], a linear polymer of orthophosphate residues, has antibacterial effects against Porphyromonas gingivalis and promotes tissue regeneration and bone formation. In this study, I examined effects of poly(P) in macrophages for the application of poly(P) in peri-implantitis treatment, and found that poly(P) suppresses the expression of inducible nitric oxide synthase and the release of nitric oxide in macrophages stimulated by lipopolysaccharide, a cell wall component of Gram-negative bacteria.
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