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Analysis of bone regeneration by mesenchymal stem cells from jaw bone and application for the treatment of jaw cleft

Research Project

Project/Area Number 23890136
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionHiroshima University

Principal Investigator

YOSHIOKA Motoko  広島大学, 病院, 歯科診療医 (00612003)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords顎骨由来 MSC / 口唇裂・口蓋裂 / 骨再生 / 再生医学 / 再生医療 / 顎骨由来MSCs
Research Abstract

A collection and a primary cell culture even little steady of mesenchymal stem cell (MSC) derived from jaw bone became possible. No significant differences in the cell proliferation and the differentiation in osteoblasts between MSCsfrom iliac bone and jaw bone. Moreover, any significant differences were not shown between the experimental side, jaw bone origin MSC mixed with the carbonated hydroxyapatite particles and the control side, iliac origin MSC with the carbonated hydroxyapatite particles in vivo experiment for bone regeneration on the beagle dogs.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (13 results)

All 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (11 results)

  • [Journal Article] Bone regeneration in artificial jaw cleft by use of carbonated hydroxyapatite particles and mesenchymal stem cells derived from iliac bone2012

    • Author(s)
      吉岡基子、谷本幸太郎、丹根由起、鷲見圭輔、粟田哲也、沖奈苗、杉山勝、加藤幸夫、丹根一夫
    • Journal Title

      International Journal of Dentistry

      Volume: 2012 Pages: 352510-352510

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone regeneration in artificial jaw cleft by use of carbonated hydroxyapatite particles and mesenchymal stem cells derived from iliac bone2012

    • Author(s)
      吉岡基子
    • Journal Title

      International Journal of Dentistry

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口蓋裂治療における骨髄由来間葉系幹細胞の役割2013

    • Author(s)
      沖奈苗、谷本幸太郎、吉岡基子、鷲見圭輔、丹根一夫
    • Organizer
      第37回日本口蓋裂学会総会・学術集会
    • Place of Presentation
      佐賀市
    • Related Report
      2012 Final Research Report
  • [Presentation] 口蓋裂治療における骨髄由来間葉系幹細胞の役割2013

    • Author(s)
      沖 奈苗
    • Organizer
      第37回日本口蓋裂学会総会・学術集会
    • Place of Presentation
      佐賀市分化会館、佐賀
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bone Regeneration by use of Mesenchymal Stem Cells for Treatment of Jaw Cleft: Part II, Orthodontic Tooth Movement into the Regenerated Bone Area2012

    • Author(s)
      吉岡基子、谷本幸太郎、丹根由起、鷲見圭輔、沖奈苗、杉山勝、丹根一夫
    • Organizer
      8th Asian Pacific Orthodontic Conference
    • Place of Presentation
      New Delhi、INDIA
    • Related Report
      2012 Final Research Report
  • [Presentation] Bone Regeneration by use of Mesenchymal Stem Cells for Treatment of Jaw Cleft: Part I, Evaluation of a New Carbonated-hydroxyapatite Scaffold2012

    • Author(s)
      谷本幸太郎、吉岡基子、鷲見圭輔、沖奈苗、坂井裕大、杉山勝、丹根一夫
    • Organizer
      8th Asian Pacific Orthodontic Conference
    • Place of Presentation
      New Delhi、INDIA
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨髄由来間葉系幹細胞を用いた顎裂閉鎖治療:顎骨骨髄有用性2012

    • Author(s)
      沖奈苗、谷本幸太郎、吉岡基子、鷲見圭輔、杉山勝、丹根一夫
    • Organizer
      第36回日本口蓋裂学会総会・学術集会
    • Place of Presentation
      京都市
    • Related Report
      2012 Final Research Report
  • [Presentation] Bone Regeneration by use of Mesenchymal Stem Cells for Treatment of Jaw Cleft: Part II, Orthodontic Tooth Movement into the Regenerated Bone Area2012

    • Author(s)
      吉岡 基子
    • Organizer
      8th Asian Pacific Orthodontic Conference
    • Place of Presentation
      New Delhi, INDIA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bone Regeneration by use of Mesenchymal Stem Cells for Treatment of Jaw Cleft: Part I, Evaluation of a New Carbonated-hydroxyapatite Scaffold2012

    • Author(s)
      谷本 幸太郎
    • Organizer
      8th Asian Pacific Orthodontic Conference
    • Place of Presentation
      New Delhi, INDIA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨髄由来間葉系幹細胞を用いた顎裂閉鎖治療:顎骨骨髄有用性2012

    • Author(s)
      沖 奈苗
    • Organizer
      第36回日本口蓋裂学会総会・学術集会
    • Place of Presentation
      国立京都国際会館、京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨髄由来未分化間葉系幹細胞を用いた顎裂部の骨再生と再生骨への歯の移動2011

    • Author(s)
      吉岡基子、他
    • Organizer
      第70回日本矯正歯科学会大会&第4回国際会議
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Bone regeneration in the treatment of bone defect in the cleft lip and palate patients with mesenchymal stem cells2011

    • Author(s)
      丹根一夫、吉岡基子、鷲見圭輔、丹根由起、谷本幸太郎
    • Organizer
      87th Congress of the European Orthodontic Society
    • Place of Presentation
      Istanbul、Turkey
    • Related Report
      2012 Final Research Report
  • [Presentation] Bone regeneration in the treatment of bone defect in the cleft lip and palate patients with mesenchymal stem cells2011

    • Author(s)
      丹根一夫
    • Organizer
      87^<th> Congress of the European Orthodontic Society
    • Place of Presentation
      Istanbul(トルコ)
    • Related Report
      2011 Annual Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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