Elucidation of target-specific mechanisms of phagosome formation through distinct receptors.
| Project/Area Number |
23890144
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Fukuoka University (2012)
Kagawa University (2011) |
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Principal Investigator |
FUJII Makoto 福岡大学, 医学部, 講師 (30398086)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ファゴサイトーシス / ライブセルイメージング |
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| Research Abstract |
Phagocytosis of pathogen and extracellular particles by macrophages is an important for immune system. In this study, we investigated the relationship between phagosome formation and signaling pathway using different phagocytotic targets. We found that Rab35, one of the small GTPase which involved in intracellular membrane trafficking, had pivotal role in TLR2 and FcR mediated phagocytosis.
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Report
(3 results)
Research Products
(13 results)
