Physiological roles of the HVCN1 channel in osteoclast
Project/Area Number |
23890145
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
General physiology
|
Research Institution | Ehime University |
Principal Investigator |
SASAKI Mari 愛媛大学, 大学院・医学系研究科, 助教 (80435817)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | イメージング / イオンチャネル / 破骨細胞 / 膜電位 |
Research Abstract |
Experimental methods for analyzing the osteoclast function wasestablished. For in vitro experiment, osteoclast precursor was co-cultured with osteoblast to differentiate to osteoclast. For in vivo experiment, mechanical testing machine was made for tibia loading. Using this machine the increasing of bone mass was evaluated. To study membrane potential of osteoclast, membrane potential change was measured by imaging technique.
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Report
(3 results)
Research Products
(9 results)