Transglutaminase-catalyzed Crosslinking Suppresses Innate Immune Signaling in the Drosophila Gut
Project/Area Number |
23890147
|
Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Immunology
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Research Institution | Kyushu University |
Principal Investigator |
SHIBATA Toshio 九州大学, 大学院・理学研究院, 助教 (00614257)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 自然免疫 / キイロショウジョウバエ / トランスグルタミナーゼ / 腸管免疫 / 腸内細菌叢 / imd経路 / IMD経路 / RNAi |
Research Abstract |
Mammalian transglutaminases (TGases) play importantroles in numerous physiological phenomena such as blood coagulation and skin formation via protein-protein crosslinking. We revealed that TGase-catalyzed protein-protein crosslinking suppresses the immune signaling pathway to maintaina buffered threshold required for immune tolerance against commensal microbes.
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Report
(3 results)
Research Products
(19 results)