Role of interferon regulatory factor(IRF) family transcription factor in microglial activation and neuropathic pain.

• Project/Area Number: 23890148
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pain science
• Research Institution: Kyushu University
• Principal Investigator: MASUDA Takahiro 九州大学, 薬学研究院, 特任助教 (80615287)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ミクログリア / 神経障害性疼痛 / IRF / 転写因子 / 中枢性疾患 / P2X4受容体

Research Abstract

We identify the interferon regulatory factor (IRF) member IRF8-IRF5 axis as a critical transcriptional regulator of microglia involved in converting into a P2X4R^hireactive phenotype, which drives neuropathic pain following peripheral nerve injury.

Research Products

• [Journal Article] Microglial Regulation of Neuropathic Pain (2013)
  • Author(s): Tsuda M, Masuda T, Tozaki-Saitoh H, Inoue K.
  • Journal Title: Journal of Pharmacological Sciences Volume: 121 Issue: 2 Pages: 89-94
  • DOI: 10.1254/jphs.12R14CP
  • NAID: 10031156937
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype. (2012)
  • Author(s): T. Masuda*, M. Tsuda*, R. Yoshinaga, H.Tozaki-Saitoh, K. Ozato, T. Tamura, K. Inoue.
  • Journal Title: Cell Rep. Volume: 1(4) Issue: 4 Pages: 334-40
  • DOI: 10.1016/j.celrep.2012.02.014
  • Peer Reviewed
• [Journal Article] IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype (2012)
  • Author(s): T.Masuda, et al
  • Journal Title: Cell Reports Volume: (In press)
  • Peer Reviewed
• [Presentation] IRF8-IRF5軸は神経障害性疼痛発現を担うP2X4受容体高発現ミクログリアを誘導する (2013)
  • Author(s): Masuda T, Tsuda M, Yoshinaga R, Iwamoto S, Nishiyama A, Nishimoto N, Tozaki-Saitoh H, Tamura T, Inoue K
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡
• [Presentation] IRF family transcription factor axis governs gene expression program in microglia that drives neuropathic pain (2012)
  • Author(s): 増田隆博
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2012-03-15
• [Presentation] IRF8 is a critical transcription factor required for transforming microglia into a reactive phenotype after nerve injury (2012)
  • Author(s): Masuda T, Tsuda M, Yoshinaga R, Tozaki-Saitoh H, Ozato K, Tamura T, Inoue K
  • Organizer: Neuroscience2012
  • Place of Presentation: ニューオリンズ(アメリカ)
• [Presentation] 転写因子IRF8を介したミクログリアATP受容体発現制御および神経障害性疼痛における役割 (2011)
  • Author(s): 増田隆博
  • Organizer: プリン研究会
  • Place of Presentation: 生理学研究所(愛知)
  • Year and Date: 2011-10-22
• [Presentation] IRF8 transcription factor directs microglia to be a hyperactive phenotype driving neuropathic pain (2011)
  • Author(s): Masuda T, Tsuda M, Yoshinaga R, Tozaki-Saitoh H, Tamura T, Inoue K
  • Organizer: EuroGlia2011
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2011-09-17
• [Presentation] IRF8 transcription factor directs microglia to be a hyperactive phenotype driving neuropathic pain (2011)
  • Author(s): Takahiro Masuda
  • Organizer: EuroGlia 2011
  • Place of Presentation: プラハ(チェコ)
  • Year and Date: 2011-09-17
• [Presentation] Interferon regulatory factor-8 は、神経損傷後に見られる脊髄ミクログリアの過活動状態への移行に重要な転写因子である (2011)
  • Author(s): 増田隆博
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: ホテル瑠璃光(石川)
  • Year and Date: 2011-09-17
• [Presentation] 転写因子IRF8によるミクログリアの活動性制御および神経障害性疼痛における役割 (2011)
  • Author(s): 増田隆博
  • Organizer: 生理学研究所研究会・グリア細胞機能から迫る脳機能解明
  • Place of Presentation: 生理学研究所(愛知)(招待講演)
  • Year and Date: 2011-06-16
• [Presentation] IRF Family Transcription Factor Axis Governs Gene Expression Program in Microglia Gating Neuropathic Pain
  • Author(s): Takahiro Masuda
  • Organizer: Purine2012
  • Place of Presentation: 福岡
• [Presentation] IRFファミリー転写因子群によるミクログリア遺伝子の発現制御と神経障害性疼痛
  • Author(s): 増田隆博
  • Organizer: 第34回日本疼痛学会
  • Place of Presentation: 熊本
• [Presentation] IRF5 is required for IRF8-derived microglial activation and contributes to neuropathic pain
  • Author(s): 増田隆博
  • Organizer: 第55回日本神経化学会大会
  • Place of Presentation: 神戸
• [Presentation] IRF8 is a critical transcription factor required for transforming microglia into a reactive phenotype after nerve injury
  • Author(s): Takahiro Masuda
  • Organizer: Neuroscience2012
  • Place of Presentation: ニューオリンズ（アメリカ）
• [Presentation] VNUT is required for producing pain hypersensitivity after peripheral nerve injury
  • Author(s): Takahiro Masuda
  • Organizer: JST-CREST international symposium
  • Place of Presentation: 東京
• [Presentation] IRF8-IRF5軸は神経障害性疼痛発現を担うP2X4受容体高発現ミクログリアを誘導する
  • Author(s): 増田隆博
  • Organizer: 第８６回日本薬理学会年会
  • Place of Presentation: 福岡
• [Remarks]
  • URL: http://yakkou.phar.kyushu-u.ac.jp/