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Effects of IL-23 and Th17 on intestinal smooth muscle contractility and its underlying mechanism

Research Project

Project/Area Number 23890149
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionKyushu University

Principal Investigator

IHARA Eikichi  九州大学, 大学病院, 助教 (80612390)

Co-Investigator(Renkei-kenkyūsha) NAKAMURA Kazuhiko  九州大学, 大学病院, 助教 (00274449)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsIL-23 / IL-17 / Th17 / 消化管平滑筋 / 消化管免疫 / カルシウム感受性 / 腸管平滑筋 / K^+脱分極刺激 / MLCK / MLCP / カルバコール / alpha-toxin
Research Abstract

The objective of the present study was to investigate effects of IL-23 and IL-17, which are associated with Th17 immune response, on the intestinal smooth muscle. In the rat intestinal smooth muscle, tissue culture with IL-23 for 3 days slightly reduced contractile response to 118 mM K+, but not to carbachol. On the other hand, tissue culture with IL-17 significantly decreased the contractile responses both to 118 mM K+and carbachol. In α-toxin permeabilized smooth muscle strips, IL-17 did not change carbachol-induced Ca^2+-sensitization. These results indicated that Th17 immune response reduced contractility in the rat intestinal smooth muscle without changing Ca^2+-sensitization via a Ca^2+/calmodulin/MLCK pathway.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (1 results)

All 2013

All Presentation (1 results)

  • [Presentation] 消化管免疫と消化管平滑筋収縮性変化2013

    • Author(s)
      伊原栄吉
    • Organizer
      第55回日本平滑筋学会総会
    • Place of Presentation
      旭川市
    • Related Report
      2012 Annual Research Report

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Published: 2011-09-05   Modified: 2019-07-29  

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