Fabrication of novel apatite coating implant based on new concept

• Project/Area Number: 23890154
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Chubu University (2012); Kyushu University (2011)
• Principal Investigator: VALANEZHAD S.A 中部大学, 生命健康科学部, 研究員 (00608870)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: Ti インプラント / アパタイトコーティング / リン酸亜鉛 / 生体適合性 / 界面強度3-2.リン酸亜鉛から HAp への組成変換 / Tiインプラント / 界面強度

Research Abstract

Aim of this study is to fabricate hydroxyapatite(HAp) coating titanium(Ti) which shows high adhesivestrength between HAp coating and Ti substrate and chemically stable with time after implantation whencompared to HAp coating prepared by plasma spraying method. Zinc phosphate coating was successfullyprepared on Ti implant using our original method employing industrial zinc phosphate coating mixed withhydrothermal treatment. Subsequently the zinc phosphate could transform to HAp by treating withappropriate calcium salt solution. Adhesive strength between obtained coating and Ti substrate was 36.7 ±17 MPa which was approximately 4 times compared to that obtained by plasma spraying method. In vitroosteoconductivity evaluated using rat bone marrow cells indicated that cell attachment, proliferation,differentiation and calcification for HAp coating were significantly higher than that for non-treated Ti. Itis concluded that novel treatment proposed in this study would be useful for ostconductive treatment ofTi implant.

Research Products

• [Journal Article] A new biocompatible coating layer applied on titanium substrates using a modified zinc phosphatizing method (2012)
  • Author(s): Alireza Valanezhad, Kanji Tsuru, Michito Maruta, Giichiro Kawachi, Shigeki Matsuya, Kunio Ishikawa.
  • Journal Title: Surface and Coatings Technology Volume: 206 Pages: 2207-2212
  • Peer Reviewed
• [Presentation] Protectivity and Adhesive Strength of Zinclipscombite Coating on 316L Stainless Steel. (2012)
  • Author(s): Alireza Valanezhad, Kanji Tsuru, Michito Maruta, Shigeki Matsuya, Kunio Ishikawa.
  • Organizer: The 24th Symposium and Annual Meeting of International Society for Ceramics in Medicine (Bioceramics24).
  • Place of Presentation: Centennial Hall Kyushu University School of Medicine, Fukuoka, Japan
• [Presentation] Hydroxyapatite Coating on ZincPhosphatized Titanium. (2012)
  • Author(s): Alireza Valanezhad, Kanji Tsuru, MichitoMaruta, Shigeki Matsuya, Kunio Ishikawa.
  • Organizer: 9th WorldBiomaterials Congress.
  • Place of Presentation: Chengdu, China
• [Presentation] A Novel HAp Coating Method on Titanium. (2011)
  • Author(s): Aireza Valanezhad, Kanji Tsuru, MichitoMaruta, Shigeki Matsuya, Kunio Ishikawa.
  • Organizer: The 23rd Symposium and Annual Meeting ofInternational Society for Ceramics inMedicine (Bioceramics 23).
  • Place of Presentation: Istanbul, Turkey.
• [Presentation] Hydroxyapatite Coating on Zinc Phosphatized Titanium
  • Author(s): Alireza Valanezhad et al.
  • Organizer: 9th World Biomaterials Congress
  • Place of Presentation: Chengdu, China
  • Invited