| Project/Area Number |
23890174
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
TAGAMI Tatsuaki 名古屋市立大学, 大学院・薬学研究科, 特任講師 (10609887)
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|---|
| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 薬学 / ナノデバイス / 癌 / トランスレーショナルリサーチ |
|---|
| Research Abstract |
We have developed a novel thermosensitive liposome formulation(HaT). To further extend our study, we proposed the new liposome formulation with more stability in the liposome. In traditional method to make doxorubixin(DOX)-loaded liposome, pH gradient is usually used. In contrast, transient metal complex-mediated retention in liposome is attractive technology in the field of liposome. We tried to encapsulate DOX in HaT liposome by using copper ion gradient.
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