The Research of Sex Hormonal Influence on the Meibomian Gland and the Ocular Surface Epithelium

• Project/Area Number: 23890181
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: SUZUKI Tomo 京都府立医科大学, 医学研究科, 客員講師 (30613236)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ドライアイ / マイボーム腺 / 性ホルモン / マイボーム腺機能不全 / 脂肪酸分析 / 加齢 / 酒さ

Research Abstract

In the present study, the methods of collection for meibomian gland secretion (meibum) without contamination were reevaluated and the analysis of fatty acid (FA) composition of meibum was conducted. In healthy volunteers meibum was composed of 40% saturated and 60% unsaturated FAs. In unsaturated Fas branched FAs were dominant and in unsaturated FAs monounsaturated was the major component. In premenstrual women the FA composition changed according to their menstrual cycle.

Research Products

• [Journal Article] Influence of aromatase absence on the gene expression and histology of the mouse meibomian gland (2013)
  • Author(s): D Darabad RR,Suzuki T,Richards SM,Jensen RV,Jakobiec FA,Zakka FR,Liu S,Sullivan DA
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 54(2) Issue: 2 Pages: 987-98
  • DOI: 10.1167/iovs.12-10992
  • Peer Reviewed
• [Journal Article] Meibomitis-related keratoconjunctivitis: implications and clinical significance of meibomian gland inflammation (2012)
  • Author(s): Suzuki T
  • Journal Title: Cornea Volume: 31Suppl1 Issue: Supplement 1 Pages: 41-4
  • DOI: 10.1097/ico.0b013e31826a04dd
• [Journal Article] Meibomitis-Related Keratoconjunctivitis : Implications and Clinical Significance of Meibomian Gland Inflammation (2012)
  • Author(s): Tomo Suzuki
  • Journal Title: Cornea Volume: (in press)
  • Peer Reviewed
• [Presentation] The Composition of Fatty Acids in Human Meibum (2013)
  • Author(s): Suzuki T, Kamada S, Tajika T, Fujiwara S, Kinoshita S
  • Organizer: ARVO 2013
  • Place of Presentation: Seattle,WA,U.S.A
  • Year and Date: 2013-05-09
• [Presentation] マイボーム腺分泌物の脂肪酸組成分析による一考察 (2013)
  • Author(s): 鈴木 智
  • Organizer: 角膜カンファランス2013
  • Place of Presentation: 白浜、和歌山県
  • Year and Date: 2013-02-14
• [Presentation] 感染アレルギー疾患の診断と治療 (2012)
  • Author(s): 鈴木 智
  • Organizer: 第66回日本臨床眼科学会、シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2012-10-25
• [Presentation] Clinical Similarities among Meibomitis-Related Keratoconjunctivitis (2012)
  • Author(s): Suzuki T, Sano Y, Yokoi N, Kinoshita S
  • Organizer: Phlyctenular Keratitis and Ocular Rosacea in Childhood ARVO 2012 For Lauderdale
  • Place of Presentation: FL, U.S.A
  • Year and Date: 2012-05-10
• [Presentation] マイボーム腺炎角結膜上皮症と酒渣性眼瞼角結膜炎の病態の類似性に関する考察 (2012)
  • Author(s): 鈴木 智
  • Organizer: 角膜カンファランス2012
  • Place of Presentation: ホテルニューオータニ.東京都
  • Year and Date: 2012-02-23
• [Presentation] マイボーム腺炎角結膜上皮症と酒渣性眼瞼角結膜炎の病態の類似性に関する考察 (2012)
  • Author(s): 鈴木智
  • Organizer: 角膜カンファランス2012第36回日本角膜学会総会・第28回日本角膜移植学会
  • Place of Presentation: ホテルニューオータニ(東京都)
  • Year and Date: 2012-02-23
• [Presentation] Meibomitis-related keratoconjunctivitis: implications and clinical significance of meibomian gland inflammation (2011)
  • Author(s): Suzuki T, Sano Y, Yokoi N, Kinoshita S
  • Organizer: ARVO 2011 For Lauderdale
  • Place of Presentation: FL, U.S.A
  • Year and Date: 2011-05-02
• [Presentation] マイボーム腺分泌物の脂肪酸組成分析による一考察
  • Author(s): 鈴木 智
  • Organizer: 角膜カンファランス2013
  • Place of Presentation: 和歌山（白浜）
• [Presentation] The Composition of Fatty Acids in Human Meibum
  • Author(s): Tomo Suzuki
  • Organizer: ARVO2013
  • Place of Presentation: Seattle, WA, U.S.A.
• [Book] あたらしい眼科 (2011)
  • Author(s): 鈴木 智
  • Publisher: 眼瞼炎.眼感染症治療戦略アップデート2011
• [Book] あたらしい眼科 (2011)
  • Author(s): 鈴木 智
  • Publisher: マイボーム腺への性ホルモンの影響.マイボーム腺研究、臨床の最前線