Effects of controlled release of NF-k8 inhibitor on bone regeneration

• Project/Area Number: 23890194
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Conservative dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: TSUCHIYA Shizu 九州歯科大学, 歯学部歯学科, 助教 (60610053)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 炎症 / NF-kB / 骨形成 / 炎症制御 / 再生医療

Research Abstract

We examined effects of steroid-coactivator MTI-II on inflammatory responses in MG63 cells. Overexpression of MTI-II in he cells failed toincrease TNFa-induced NF-k8-luciferase activity in a dose-dependent manner as well as TNFa-induced expression of matrix metallopeptidase-9 (MMP-9) mRNA , a target gene of NF-kB. These results suggest that MT1-II may may have an potential as an anti-inflaammatory drug

Research Products

• [Journal Article] The current and future therapies of bone regeneration to repair bone defects.Special issue Tissue Engineering in Dentistry (2012)
  • Author(s): Jimi E,Hirata S,Osawa K,Terashita T,Kitamura C,Fukushima H
  • Journal Title: nternational Journal of Dentistry Volume: 2012 Pages: 148261-148261
  • Peer Reviewed
• [Presentation] 骨芽細胞様細胞の炎症応答においてMTI-IIが示す抗炎症作用の検討 (2012)
  • Author(s): 平田志津,岡本一起,寺下正道,北村知昭
  • Organizer: 第136回日本歯科保存学会20120春季学術大会
  • Place of Presentation: 沖縄
  • Year and Date: 2012-06-29
• [Presentation] ステロイドコアクチベーターMTI-IIによる抗炎症作用の検討 (2012)
  • Author(s): 平田志津,自見英治郎,寺下正道,北村知昭
  • Organizer: 第72回九州歯科学会総会
  • Place of Presentation: 北九州
  • Year and Date: 2012-05-20
• [Presentation] ステロイドコアクチベーターMTI-IIによる骨芽細胞様細胞への影響 (2012)
  • Author(s): 平田-土屋志津,岡本一起,寺下正道,北村知昭
  • Organizer: 第137回日本歯科保存学会20120秋季学術大会
  • Place of Presentation: 広島
• [Presentation] A role of MTI-II in osteoblast differentiation (2012)
  • Author(s): Jimi E,Terashita M,Kitamura C,Hirata-Tsuchiya
  • Organizer: The Fifth Japan-Korea Joint Symposium on Bio-microsensing Technology
  • Place of Presentation: Japan
• [Presentation] MI-IIの骨芽細胞様細胞に対する抗炎症作用の検討 (2012)
  • Author(s): 平田-土屋志津,寺下正道,岡本一起,北村知昭
  • Organizer: 第10回日本再生歯科医学会学術大会
  • Place of Presentation: 神戸
• [Presentation] A role of MTI-II in osteoblast differentiation (2012)
  • Author(s): Tsuchiya-Hirata S
  • Organizer: The Fifth Japan-Korea Joint Symposium on Bio-microsensing Technology
  • Place of Presentation: Kitakyushu, Japan
• [Presentation] MTI-IIの骨芽細胞様細胞に対する抗炎症作用の検討 (2012)
  • Author(s): 平田-土屋志津
  • Organizer: 第10回日本再生歯科医学会学術大会
  • Place of Presentation: 神戸
• [Presentation] 骨芽細胞様細胞の炎症応答においてMTI-IIが示す抗炎症作用の検討 (2012)
  • Author(s): 平田志津
  • Organizer: 第136回日本歯科保存学会2012年春季学術大会
  • Place of Presentation: 沖縄
• [Presentation] ステロイドコアクチベーターMTI-IIによる骨芽細胞様細胞への影響 (2012)
  • Author(s): 平田－土屋志津
  • Organizer: 第137回日本歯科保存学会2012年秋季学術大会
  • Place of Presentation: 広島
• [Presentation] NF-κB inhibits BMP signal by interfering with the DNA binding of Smads (2011)
  • Author(s): Shizu Hirata Tsuchiya
  • Organizer: The 4th Japan-Korea joint symposium on bio-microsensing technology
  • Place of Presentation: 九州工業大学戸畑キャンパス
  • Year and Date: 2011-10-28
• [Presentation] BMP誘導性骨形成にNF-κB阻害剤が与える影響 (2011)
  • Author(s): 土屋(平田)志津
  • Organizer: 日本再生歯科医学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-09-10
• [Presentation] NF-κB阻害剤はBMPによる骨形成を促進する (2011)
  • Author(s): 土屋(平田)志津
  • Organizer: 日本歯科保存学会
  • Place of Presentation: 大阪国際交流センター