Development of a new therapy for xerostomia using mechanobiology

• Project/Area Number: 23890195
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: KONDO Yusuke 九州歯科大学, 歯学部, 助教 (00611287)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 唾液腺 / 顎下腺 / 口腔乾燥症 / メカノバイオロジー / AQP5 / NKCC1

Research Abstract

I planned this study to develop a new therapy for xerostomia using mechanobiologycombined with muscarinic agonists. As a result, it was revealed that salivary gland function is temperature-sensitive, which is associated with intracellular Ca2+concentration increase. In addition, it is also clarified that the saliva secretion is updated in hypotonic environment, and the involvement of Na+-K+-2Clcotransporter activity has been suggested as the cause.

Research Products

• [Journal Article] Hosokawa, Thermal influence of saliva secretionex vivo in the mouse submandibular gland (2013)
  • Author(s): T Mukaibo, T Nakamoto, Y Kondo, M Kidokoro, A Imamura, C Masaki and R
  • Journal Title: Open Journal of Stomatology Volume: 3 Pages: 83-88
  • Peer Reviewed
• [Journal Article] Thermal influence of saliva secretion ex vivo in the mouse submandibular gland (2013)
  • Author(s): TaroMukaibo
  • Journal Title: Open Journal of Stomatology Volume: 3 Issue: 01 Pages: 83-88
  • DOI: 10.4236/ojst.2013.31015
  • Peer Reviewed
• [Presentation] Hyper-and hypo-osmolarity effect mice submandiblar gland function (2013)
  • Author(s): YusukeKondo
  • Organizer: Asia-pacific conference in fukuoka 2013
  • Place of Presentation: Fukuoka
• [Presentation] Tannic acid inhibits salivation from ex vivo mouse submandibular glands (2013)
  • Author(s): AtsusiImamura
  • Organizer: The 91th International Association for Dental Research
  • Place of Presentation: Seattle
• [Presentation] A Physiological Comparison of the Three Major Mammalian Salivary Glands (2012)
  • Author(s): TetsujiNakamoto
  • Organizer: The 90th General Session & Exhibition of the IADR
  • Place of Presentation: Iguaz
• [Presentation] Hyperand hypo- osmolarity on submandibular glandfunction (2011)
  • Author(s): M Kidokoro, A Imamura, Y Kondo, T Mukaibo, C Masaki, R Hosokawa and T Nakamoto
  • Organizer: The 59thAnnual Meeting of Japanese Association for Dental Research
  • Place of Presentation: Hiroshima city
  • Year and Date: 2011-10-09
• [Presentation] Hyper- and hypo-osmolarity on submandibular gland function (2011)
  • Author(s): Manami Kidokoro, Atsushi Imamura, Yusuke Kondo, Taro Mukaibo, Chihiro Masaki, Ryuji Hosokawa, Tetsuji Nakamoto
  • Organizer: 第59回国際歯科研究学会日本部会総会・学術大会
  • Place of Presentation: 広島