| Project/Area Number |
23890202
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
YAMADA Takeshi 北里大学, 大学院・感染制御科学府, 助教 (00608367)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ボトロマイシン / ペプチド合成 / アミジン / 抗 MRSA / 抗 VRE / Bottromycin / 抗MRSA / 抗VRE / 固相合成 / 抗生物質 / ペプチド / 合成化学 / 有機化学 |
|---|
| Research Abstract |
We have developed the convergent synthetic route to bottromycins (BTMs), which exhibit a potent antibiotic activity against MRSAand VRE with novel mode of action. In the course of SAR study, we found the methyl groups of unnatural amino acids, 3-Me-Pro and 3-Me-Phe, are the important functionality for their biological activities. The three-dimensional structure of BTM was investigated to improve understanding of SAR, and to design the new BTM analog which reveals the potent antibiotic activity.
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