Global analysis of two-component signal transduction systems in Streptococcus mutans

• Project/Area Number: 23890207
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Showa University
• Principal Investigator: TANIGUCHI Makoto 昭和大学, 歯学部, 助教 (50611175)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: Two-component system / Streptococcus mutans / リン酸化解析 / 環境適応 / リポタンパク質

Research Abstract

Streptococcus mutans uses two-component signal transduction systems (TCSs) to monitor and respond to changes of various environmental conditions in human oral cavity. However, mechanisms of TCSs in stress tolerance have been still unknown. In this study, we identified 14 components of TCSs involved in resistance to chlorhexidine, a medicated component of tooth powder.

Research Products

• [Journal Article] Relationship between CiaRH and lipoprotein OpcC in the acid tolerance of Streptococcus mutans (2013)
  • Author(s): Taniguchi M, Arimoto T, Igarashi T
  • Journal Title: Dental Medicine Research Volume: 33 Pages: 56-67
  • NAID: 10031166795
  • Peer Reviewed
• [Journal Article] Rapid detection and identification of Streptococcus ratti by a species-specific PCR method (2012)
  • Author(s): Nishio J, Taniguchi M, Higashi J, Takahashi M, Ando T, Hasegawa T, Igarashi T
  • Journal Title: Anaerobe Volume: 18 Pages: 44-47
  • Peer Reviewed
• [Presentation] Rothia dentocariosa induces TNF-alpha production in a TLR2 dependent manner (2013)
  • Author(s): Kataoka H, Arimoto T, Taniguchi M, Fukamachi H, Morisaki H, Cho K, Yamamoto M, Kuwata H
  • Organizer: 第86回 日本細菌学会総会
  • Place of Presentation: 千葉県千葉市
  • Year and Date: 2013-03-19
• [Presentation] Rothia dentocariosa induces TNF-alpha production in TLR2 dependent manner (2013)
  • Author(s): Hideo Kataoka
  • Organizer: 日本細菌学会
  • Place of Presentation: 幕張メッセ
• [Presentation] Streptococcus mitis のcholine binding protein E欠損株の性状 (2012)
  • Author(s): 森崎弘史, 有本隆文, 片岡嗣雄, 谷口誠,深町はるか
  • Organizer: 第54回 歯科基礎医学会学術大会
  • Place of Presentation: 福島県郡山市
  • Year and Date: 2012-09-14
• [Presentation] Relationship between lipoprotein PpiA and scavenger receptors in S.grodnii evasion of phagocytosis (2012)
  • Author(s): K.Cho, T.Arimoto, M.Taniguchi, T.Ando, M.Yamamoto, T.Igarashi
  • Organizer: 第85回日本細菌学会
  • Place of Presentation: 長崎県長崎市
  • Year and Date: 2012-03-29
• [Presentation] Streptococcus mitisのcholine binding protein E欠損株の性状 (2012)
  • Author(s): 森崎弘史
  • Organizer: 第54回歯科基礎医学会総会
  • Place of Presentation: 奥羽大学
• [Presentation] Relationship between lipoprotein OpcC and two-component system CiaH in acid tolerance of Streptococcus mutans (2011)
  • Author(s): Taniguchi M, Arimoto T, Nishio J, Higashi J, Igarashi T
  • Organizer: 第84回 日本細菌学会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2011-09-09
• [Presentation] Relationship between lipoprotein PpiA and scavenger receptors in S. grodnii evasion of phagocytosis (2011)
  • Author(s): Cho K, Arimoto T, Taniguchi M, Ando T, Yamamoto M, Igarashi T
  • Organizer: 第84回 日本細菌学会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2011-09-09
• [Presentation] Identification of a lipoprotein PrtM involved in osmotic stress response of Streptococcus mutans (2011)
  • Author(s): Kunii M, Arimoto T, Taniguchi M, Chou K, FukuraK, Hasegawa T, Igarashi T
  • Organizer: 第84回 日本細菌学会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2011-09-09
• [Presentation] Relationship between lipoprotein OpcC and two-component system CiaH in acid tolerance of Streptococcus mutans (2011)
  • Author(s): M.Taniguchi, T.Arimoto, J.Nishio, J.Higashi, T.Igarashi
  • Organizer: 第84回日本細菌学会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2011-09-09
• [Presentation] Identification of a lipoprotein PrtM involved in osmotic stress response of Streptococcus mutans (2011)
  • Author(s): M.Kunii, T.Arimoto, M.Taniguchi, K.Chou, K.Fukura, T.Hasegawa, T.Igarashi
  • Organizer: 第84回日本細菌学会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2011-09-09
• [Presentation] Functional analysis of a putative ABC transporter, LivFGMHK, in Streptococcus mutans (2011)
  • Author(s): Arimoto T, Taniguchi M, Nishio J, AndoT, Igarashi T
  • Organizer: American Society for Microbiology
  • Place of Presentation: アメリカニューオーリンズ州
  • Year and Date: 2011-05-23