Characterization of immunoregulation by Th17 cell on Periodontal disease model

• Project/Area Number: 23890217
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Nihon University
• Principal Investigator: KOBAYASHI Ryoki 日本大学, 松戸歯学部, 助手(専任扱) (10609085)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 感染症 / 免疫学 / 歯周疾患 / TH17 / 口腔粘膜 / Th17

Research Abstract

In order to clarify the mechanism of Periodontal diseases, we characterized the immunoregulatory effect by Th17 cells in the inflamed gingiva of mice with alveolar bone resorption. In this study, we employ Aggregatibacter actinomycetemcomitansone, one of the higher risk factors for induce of inflammation to gingiva and alveolar bone loss.

Research Products

• [Journal Article] Characterization of Inflammation-derived CD11c+ Dendritic cells in Periodontal disease mouse model.2012 (2013)
  • Author(s): Kobayashi, R., T. Ochiai, T.Hashizume-Takizawa, K. Fujihashi and M. Yamamoto.
  • Journal Title: Int. J. Oral-Med. Sci. Volume: 11(4) Pages: 300-306
• [Journal Article] Characterization of Inflammation-derived CD11c+ Dendritic cells in Mouse Model of Periodontal Disease (2013)
  • Author(s): Ryoki Kobayashi
  • Journal Title: International Journal of Oral Medical Science Volume: 11 Pages: 1-7
  • NAID: 130003375188
  • Peer Reviewed
• [Presentation] Induction of Foxp3+CD4+ Treg cell by inflammatory-induced gingival dendritic cells (2012)
  • Author(s): Kobayashi, R.
  • Organizer: International Associations for Dental Research
  • Place of Presentation: Fos do Iguacus, Brazil
• [Presentation] Severe Periodontal tissue damaged by Aggregatibacter actinomycetemcomitans in mouse model. (2012)
  • Author(s): Kobayashi, R.
  • Organizer: 41st Japanese Society for Immunologist
  • Place of Presentation: Kobe, Japan
• [Presentation] Increased Numbers of ICAM-1^+Dendritic Cells and CD4^+ Tree Cell in Inflamed Gingival with Bone Loss (2011)
  • Author(s): Ryoki, Kobayashi
  • Organizer: 第53回歯科基礎医学会学術大会・総会
  • Place of Presentation: 長良川国際会議場
  • Year and Date: 2011-10-01
• [Presentation] Increased Numbers of ICAM-1+ Dendritic Cells and CD4+ Treg Cells in Inflamed Gingiva with Bone Loss.
  • Author(s): Kobayashi, R. and M. Yamamoto.
  • Organizer: 53rd Annual Meeting of Japanese Association for Oral Biology.
  • Place of Presentation: Gifu, Japan
• [Presentation] Induction of Foxp3+CD4+ Treg cell by inflammatory-induced gingival dendritic cells.
  • Author(s): Kobayashi, R., S. Yuzawa, T. Hashizume, T. Ochiai and M. Yamamoto.
  • Organizer: International Associations for Dental Research
  • Place of Presentation: Fos do Iguacus, Brazil
• [Presentation] Severe Periodontal tissue damaged by Aggregatibacter actinomycetemcomitans in mouse model.
  • Author(s): Kobayashi, R., T. Ochiai, T. Hashizume1, K. Fujihashi, and M. Yamamoto.
  • Organizer: 41^<st> Japanese Society for Immunologist
  • Place of Presentation: Kobe, Japan