Study on the application to oral cancer treatment drug of Ni2+ion

Research Project

Project/Area Number	23890218
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Pathobiological dentistry/Dental radiology
Research Institution	Nihon University
Principal Investigator	OMAGARI Daisuke 日本大学, 歯学部, 専修研究員 (10608699)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	金属イオン / 癌 / シグナル伝達
Research Abstract	IL-8 plays an important role by put the progression of malignant tumors. Ni compounds have been recognized as a carcinogen, but there are many unclear points in the context of IL-8. We studied the effect of Ni2 + ions for the secretion of IL-8 spontaneous using oral squamous cell carcinoma cell lines, As a results, Ni ions inhibited IL-8 secretion in a dose-and time-dependent manner. It indicated that the cluster of histidine at the N-terminal part of the molecule of p50 is required for binding of the Ni ions.