Study on the application to oral cancer treatment drug of Ni2+ion
Project/Area Number |
23890218
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Pathobiological dentistry/Dental radiology
|
Research Institution | Nihon University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 金属イオン / 癌 / シグナル伝達 |
Research Abstract |
IL-8 plays an important role by put the progression of malignant tumors. Ni compounds have been recognized as a carcinogen, but there are many unclear points in the context of IL-8. We studied the effect of Ni2 + ions for the secretion of IL-8 spontaneous using oral squamous cell carcinoma cell lines, As a results, Ni ions inhibited IL-8 secretion in a dose-and time-dependent manner. It indicated that the cluster of histidine at the N-terminal part of the molecule of p50 is required for binding of the Ni ions.
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Report
(3 results)
Research Products
(2 results)