| Project/Area Number |
23890222
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
TASHIMA Itaru 鶴見大学, 歯学部, 臨床助手 (10612004)
|
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| Project Period (FY) |
2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 免疫染色 / 樋状根 / SHH signaling pathway / C57L/J |
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| Research Abstract |
The aim of this study was to identify the gene for influencing to tooth root form using C57L/J strain mice(LJ mice) and C57BL/6J strain mice(B6 mice). We performed immunohistochemistry(IHC) to analyze the expression patterns of sonic hedgehog(SHH) and GLI-Kruppel family member GLI1(Gli1) in postnatal days 10, 11, 12.
Expression patterns of SHH and Gli1 showed differences in tooth root bifurcation area between LJ mice and B6 mice. It is suggested that SHH signaling pathway is involved to tooth root formation in C57L/J strain mice.
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