Molecular mechanisms of up-regulation of regulatory T cells induced by asbestos
| Project/Area Number |
23890237
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Kawasaki Medical School |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | アスベスト / がん / 腫瘍免疫 / 制御性 T 細胞 / アポトーシス / 悪性中皮腫 / 制御性T細胞 / 転写因子 / FOXO1 / 免疫 |
|---|
| Research Abstract |
We previously reported that MT-2 cells, model of regulatory T cells, showed resistance to high concentration of asbestos and up-regulation of IL-10 and TGFβ production after long-term exposure to low concentration of asbestos. In this study, we analyzed the involvement of transcription factors, FoxP3, NFAT and FoxO1, in change of functions of MT-2 cells induced by asbestos. It was revealed that long-term exposure to asbestos reduced expression of FoxP3 and FoxO1, and FoxO1 regulated apoptosis induced by asbestos. These results are important for elucidating the mechanism of up-regulation of regulatory T cell induced by asbestos.
|
Report
(3 results)
Research Products
(60 results)
-
[Journal Article] Alteration of cytoskeletal molecules in a human T cell line caused by continuous exposure to chrysotile asbestos.2013
Author(s)
Maeda, M., Chen, Y., Kumagai-Takei, N., Hayashi, H., Matsuzaki, H., Lee, S., Hiratsuka, JI., Nishimura, Y., Kimura, Y., Otsuki T.
-
Journal Title
Immunobiology
Volume: (in press)
Issue: 9
Pages: 1184-91
DOI
Related Report
Peer Reviewed
-
[Journal Article] Effect of Asbestos Exposure on Differentiation of Cytotoxic T Lymphocytes in MLR of Human PBMCs.2013
Author(s)
Kumagai-Takei, N., Nishimura, Y., Maeda, M., Hayashi, H., Matsuzaki, H., Lee, S., Hiratsuka, J., Otsuki, T.
-
Journal Title
Am. J. Respir. Cell Mol. Biol.
Volume: (in press)
Related Report
Peer Reviewed
-
[Journal Article] Altered functions of alveolar macrophages and NK cells involved in asbestos-related diseases.2013
Author(s)
Nishimura, Y., Maeda, M.,Kumagai-Takei, N., Lee, S., Matsuzaki, H., Wada, Y., Nishiike-Wada, T., Iguchi, H., Otsuki, T.
-
Journal Title
Environ. Health Prev. Med.
Volume: 18(3)
Issue: 3
Pages: 198-204
DOI
NAID
Related Report
Peer Reviewed
-
[Journal Article] Resistance to asbestos-induced apoptosis with continuous exposure to crocidolite ona human T cell.2012
Author(s)
Maeda, M., Yamamoto, S., Chen, Y.,Kumagai-Takei, N., Hayashi, H., Matsuzaki, H., Lee, S., Hatayama, T., Miyahara, N., Katoh, M., Hiratsuka, J., Nishimura, Y., Otsuki, T.
-
Journal Title
Sci. Total Environ.
Volume: 429
Pages: 174-182
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
