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Analyses of host defense mechanism with herpes virus infections

Research Project

Project/Area Number 23890238
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionKawasaki Medical School

Principal Investigator

YAMAMOTO Takenobu  川崎医科大学, 医学部, 講師 (50379799)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsヘルペスウイルス / アポトーシス / 細胞傷害性 T 細胞 / ウイルス複製 / 細胞傷害性T細胞 / 単純ヘルペスウイルス / 水痘・帯状疱疹ウイルス / 細胞障害性T細胞 / ランゲルハンス細胞
Research Abstract

Herpes virus makes the condition which the virus grow efficiently. Herpes virus evades the host defence by minimal expression of viral antigens. On the other hand, host immune system induces cytotoxic T cell-infiltration to the skin lesions and viral infected cells apoptosis. Small vesicles are induced by herpes virus infection in health human because of the relationship between viral and host defence factors. Large vesicles are induced in the immune suppressed condition that is more predominant in viral factors than in host defence factors.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (64 results)

All 2013 2012 2011

All Journal Article (23 results) (of which Peer Reviewed: 12 results) Presentation (39 results) (of which Invited: 2 results) Book (2 results)

  • [Journal Article] EBV関連皮膚リンパ球増殖症2013

    • Author(s)
      平井陽至,山本剛伸,三宅智子,山内晶子,鈴木大介,藤井一恭,岩月啓氏
    • Journal Title

      血液内科

      Volume: 66巻 Pages: 219-225

    • NAID

      40019614186

    • Related Report
      2012 Final Research Report
  • [Journal Article] 鼻部に生じたメトトレキサート関連リンパ増殖性疾患の1例2012

    • Author(s)
      渡邊友也,蒲原毅,松倉節子,山本剛伸,岩月啓氏,池澤善郎
    • Journal Title

      皮膚科の臨床

      Volume: 54巻 Pages: 1835-1839

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 伝染性単核球症おとなとこどもの症状は同じ〓Gianotti 症候群も EBV〓2012

    • Author(s)
      三宅智子, 平井陽至, 岩月啓氏, 山本剛伸
    • Journal Title

      VisualDermatology

      Volume: 11巻 Pages: 1264-1266

    • Related Report
      2012 Final Research Report
  • [Journal Article] 皮膚病変におけるウイルス感染検査と読み方2012

    • Author(s)
      山本剛伸
    • Journal Title

      日本皮膚科学会誌

      Volume: 122巻 Pages: 3405-3408

    • Related Report
      2012 Final Research Report
  • [Journal Article] Diversity of Epstein-Barr virus BamHI-A rightward transcripts and their expression patterns in the lytic and latent infections2012

    • Author(s)
      Yamamoto T, Iwatsuki K
    • Journal Title

      J Med Microbiol

      Volume: 61巻 Issue: 10 Pages: 1445-1453

    • DOI

      10.1099/jmm.0.044727-0

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Valproic acid inhibits proliferation of EB virus-infectednatural killer cells2012

    • Author(s)
      Fujii K, Suzuki N, Yamamoto T, Duzuki D,Iwatsuki K
    • Journal Title

      Hematology

      Volume: 17巻 Issue: 3 Pages: 163-169

    • DOI

      10.1179/102453312x13376952196494

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oculomucosal and gastrointestinal involvement in Epstein-Barr virus-associated hydroa vacciniforme.2012

    • Author(s)
      Yamamoto T, Hirai Y, Miyake T, Yamasaki O, Morizane S, Iwatsuki K
    • Journal Title

      Eur J Dermatol

      Volume: 22 Issue: 3 Pages: 380-383

    • DOI

      10.1684/ejd.2012.1665

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydroa vacciniforme is associated with increased numbers of Epstein-Barrvirus-infected γδT-cells2012

    • Author(s)
      Hirai Y, et al
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 132 Issue: 5 Pages: 1401-1408

    • DOI

      10.1038/jid.2011.461

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 種痘様水疱症の1例2012

    • Author(s)
      鈴木薫,竹中祐子,石黒直子,川島眞,平井陽至,山本剛伸,岩月啓氏
    • Journal Title

      臨床皮膚科

      Volume: 66巻 Pages: 295-298

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barrウイルス感染症と種痘様水疱症2012

    • Author(s)
      平井陽至,山本剛伸,三宅智子,山内晶子,藤井一恭,森実真,岩月啓氏
    • Journal Title

      MBDerma

      Volume: 191巻 Pages: 295-298

    • Related Report
      2012 Final Research Report
  • [Journal Article] グラム染色・Tzanck 試験-コツと落とし穴-2012

    • Author(s)
      山本剛伸
    • Journal Title

      Visual Dermatology

      Volume: 11巻 Pages: 378-381

    • Related Report
      2012 Final Research Report
  • [Journal Article] Proteomic study identified HSP 70kDa protein 1A as a possible therapeutic target, in combination with histone deacetylase inhibitors, for lymphoid neoplasms2012

    • Author(s)
      Fujii K, Suzuki N, Ikeda K, Hamada T,Yamamoto T, Kondo T, Iwatsuki K
    • Journal Title

      JProteomics

      Volume: 75巻 Issue: 4 Pages: 1401-1410

    • DOI

      10.1016/j.jprot.2011.11.010

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phenotypic analysis in a case of hydroa vacciniforme-like eruptions associated with chronic activeEpstein-Barr virus disease of γδ T cells2012

    • Author(s)
      Tanaka C, Hasegawa M, Fujimoto M,Iwatsuki K, Yamamoto T, Yamada K, Kawa K, Saikawa Y, Toga A, Wada T, Takehara K, Yachie A
    • Journal Title

      Br J Dermatol

      Volume: 166巻 Issue: 1 Pages: 216-218

    • DOI

      10.1111/j.1365-2133.2011.10512.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] グラム染色・Tzanck試験 -コツと落とし穴-2012

    • Author(s)
      山本 剛伸
    • Journal Title

      Visual Dermatology

      Volume: 11 Pages: 378-381

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Epstein-Barrウイルス感染症と種痘様水疱症2012

    • Author(s)
      平井 陽至
    • Journal Title

      MB Derma

      Volume: 191 Pages: 48-53

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 種痘様水疱症の1例2012

    • Author(s)
      鈴木 薫
    • Journal Title

      臨床皮膚科

      Volume: 66 Pages: 295-298

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 皮膚病変におけるウイルス感染検査と読み方2012

    • Author(s)
      山本 剛伸
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 122 Pages: 3405-3408

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Proteomic study identified HSP 70kDa protein 1A as a possible therapeutic target, in combination with histone deacetylase inhibitors, for lymphoid neoplasms2012

    • Author(s)
      Fujii K
    • Journal Title

      J Proteomics

      Volume: 75 Pages: 1401-1410

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 皮膚病変のウイルス感染検査2011

    • Author(s)
      山本剛伸
    • Journal Title

      日本皮膚科学会誌

      Volume: 121巻 Pages: 2930-2933

    • NAID

      10031165077

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Epstein-Barrウイルス関連T/NKリンパ球増殖症と診断した63症例の検討2011

    • Author(s)
      平井陽至,山本剛伸,三宅智子,山内晶子,藤井一恭,岩月啓氏
    • Journal Title

      皮膚病診療

      Volume: 33巻 Pages: 1174-1178

    • Related Report
      2012 Final Research Report
  • [Journal Article] Dendritic cell subsets and immunological milieu in inflammatory human papilloma virus-related skin lesions2011

    • Author(s)
      Nakayama Y, et al
    • Journal Title

      Journal of Dermatological Science

      Volume: 63 Issue: 3 Pages: 173-183

    • DOI

      10.1016/j.jdermsci.2011.05.006

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic cell subsets and immunological milieu in inflammatory human papilloma virus-related skin lesions2011

    • Author(s)
      Nakayama Y
    • Journal Title

      J Dermatol Sci

      Volume: 63 Pages: 173-183

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barrウイルス関連T/NKリンパ球増殖症と診断した63症例の検討2011

    • Author(s)
      平井陽至
    • Journal Title

      皮膚病診療

      Volume: 33 Pages: 1174-1178

    • Related Report
      2011 Annual Research Report
  • [Presentation] Pathogenic cell types, molecular mechanisms and prognostic factors in EB virus-associated cutaneous T/NK lymphoproliferative disorders2013

    • Author(s)
      Iwatsuki K
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Edinburgh International
    • Related Report
      2012 Final Research Report
  • [Presentation] Eradication of cutaneousherpesvirus infections by nucleic acid sensors and cytotoxic T lymphocyte mediated apoptotic processes2013

    • Author(s)
      Hirai Y
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Edinburgh International Conference Centre(EICC) (Edinburgh, Scotland)
    • Related Report
      2012 Final Research Report
  • [Presentation] EBV関連疾患の病変部における潜伏感染の維持・再活性化メカニズムの解析2013

    • Author(s)
      山本剛伸
    • Organizer
      第22回EBウイルス感染症研究会
    • Place of Presentation
      ベルサール八重洲(東京)
    • Related Report
      2012 Final Research Report
  • [Presentation] Immediate-early (IE) genereactivation signal, BZLF1, is a molecular marker for a poor prognosis of EBV-associated T/NKlymphoproliferative skin diseases2013

    • Author(s)
      Iwatsuki K
    • Organizer
      2nd World Congress ofCutaneous Lymphomas
    • Place of Presentation
      MCI Deutschland GmbH(Berlin)
    • Related Report
      2012 Final Research Report
  • [Presentation] VZV・HSV感染に伴う多彩な皮膚臨床像について2013

    • Author(s)
      山本剛伸
    • Organizer
      第5回HZ・S研究会
    • Place of Presentation
      ストリングスホテル東京インターコンチネンタル(東京)
    • Related Report
      2012 Final Research Report
  • [Presentation] VZV・HSV感染に伴う多彩な皮膚臨床像について2013

    • Author(s)
      山本 剛伸
    • Organizer
      第5回 HZ・S研究会
    • Place of Presentation
      ストリングスホテル東京インターコンチネンタル (東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Immediate-early (IE) gene reactivation signal, BZLF1, is a molecular marker for a poor prognosis of EBV-associated T/NKlymphoproliferative skin diseases2013

    • Author(s)
      Iwatsuki K
    • Organizer
      2nd World Congress of Cutaneous Lymphomas
    • Place of Presentation
      MCI Deutschland GmbH (Berlin)
    • Related Report
      2012 Annual Research Report
  • [Presentation] EBV関連疾患の病変部における潜伏感染の維持・再活性化メカニズムの解析2013

    • Author(s)
      山本 剛伸
    • Organizer
      第22回 EBウイルス感染症研究会
    • Place of Presentation
      ベルサール八重洲 (東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Eradication of cutaneous herpesvirus infections by nucleic acid sensors and cytotoxic T lymphocyte-mediated apoptotic processes2013

    • Author(s)
      Hirai Y
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Edinburgh International Conference Centre (EICC) (Edinburgh, Scotland)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pathogenic cell types, molecular mechanisms and prognostic factors in EB virus-associated cutaneous T/NK lymphoproliferative disorders2013

    • Author(s)
      Iwatsuki K
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Edinburgh International Conference Centre (EICC) (Edinburgh, Scotland)
    • Related Report
      2012 Annual Research Report
  • [Presentation] EBウイルス関連疾患の予後に関する追跡調査2012

    • Author(s)
      三宅智子
    • Organizer
      EBウイルス感染症研究会
    • Place of Presentation
      ベルサール八重洲.東京都中央区
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 免疫能と皮疹形成のメカニズム-単純疱疹と帯状疱疹の共通点・相違点-2012

    • Author(s)
      山本剛伸
    • Organizer
      第4回HZ研究会
    • Place of Presentation
      ストリングホテル東京インターコンチネンタル,東京港区(招待講演)
    • Year and Date
      2012-01-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cathelicidin antimicrobialpeptide LL-37 augments anti-viralactivity induced by double-stranded RNA in keratinocytes2012

    • Author(s)
      Takiguchi T
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      ロワジールホテル那覇 (那覇市)
    • Related Report
      2012 Final Research Report
  • [Presentation] Pemphigus IgG treated keratinocytes are susceptible to herpes simplex virus induced cell dissociation, but protective to virus replication2012

    • Author(s)
      Kamiya K
    • Organizer
      The37th Annual Meeting of the JapaneseSociety for Investigative Dermatology
    • Place of Presentation
      ロワジールホテル那覇 (那覇市)
    • Related Report
      2012 Final Research Report
  • [Presentation] Interferon gamma enhancesanti-viral activity induced by double-stranded RNA in keratinocytes2012

    • Author(s)
      Kajita A
    • Organizer
      The37th Annual Meeting of the JapaneseSociety for Investigative Dermatology
    • Place of Presentation
      ロワジールホテル那覇(那覇市)
    • Related Report
      2012 Final Research Report
  • [Presentation] A reactivation signal, BZLF1expression, is a prognostic marker for severe hydroa vacciniforme and hypersensitivity to mosquito bites2012

    • Author(s)
      Miyake T
    • Organizer
      The37th Annual Meeting of the JapaneseSociety for Investigative Dermatology
    • Place of Presentation
      ロワジールホテル那覇(那覇市)
    • Related Report
      2012 Final Research Report
  • [Presentation] Ataxia telangiectasiapatients cannot cause severe Herpes Simplex because of disturbed Herpes simplex virus replication by ATM mutation2012

    • Author(s)
      Yamamoto T
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      ロワジールホテル那覇(那覇市)
    • Related Report
      2012 Final Research Report
  • [Presentation] ヘルペスウイルス感染に伴うウイルス側・宿主側からみた免疫回避・誘導のメカニズム2012

    • Author(s)
      山本剛伸
    • Organizer
      第8回中国研究皮膚科セミナー
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 天疱瘡に合併するヘルペスウイルス感染症とその病態への関与2012

    • Author(s)
      神谷浩二
    • Organizer
      第64回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      広島国際会議場(広島市)
    • Related Report
      2012 Final Research Report
  • [Presentation] EBV関連T/NKリンパ球増殖症における皮膚病変と末梢血リンパ球サブセットについて2012

    • Author(s)
      平井陽至
    • Organizer
      第19回ヘルペス感染症フォーラム
    • Place of Presentation
      京王プラザホテル札幌(札幌市)
    • Related Report
      2012 Final Research Report
  • [Presentation] EBウイルス関連疾患の予後に関する追跡調査2012

    • Author(s)
      三宅智子
    • Organizer
      第111回日本皮膚科学会総会・学術大会
    • Place of Presentation
      京都国際会館(京都市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 皮膚病変におけるウイルス感染検査と読み方2012

    • Author(s)
      山本剛伸
    • Organizer
      第111回日本皮膚科学会総会・学術大会
    • Place of Presentation
      京都国際会館(京都市)
    • Related Report
      2012 Final Research Report
  • [Presentation] Clues for Epstein-Barr virusreactivation with the subsequent outbreak of immune responses in skin lesions of hypersensitivity to mosquito bites2012

    • Author(s)
      Iwatsuki K
    • Organizer
      SID72th Annual Meeting
    • Place of Presentation
      Raleigh ConventionCenter (Raleigh, North Carolina)
    • Related Report
      2012 Final Research Report
  • [Presentation] Clues for Epstein-Barr virus reactivation with the subsequent outbreak of immune responses in skin lesions of hypersensitivity to mosquito bites.2012

    • Author(s)
      Iwatsuki K
    • Organizer
      SID 72th Annual Meeting
    • Place of Presentation
      Raleigh Convention Center (Raleigh, North Carolina)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 皮膚病変におけるウイルス感染検査と読み方2012

    • Author(s)
      山本 剛伸
    • Organizer
      第111回 日本皮膚科学会総会・学術大会
    • Place of Presentation
      京都国際会館 (京都市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] EBウイルス関連疾患の予後に関する追跡調査2012

    • Author(s)
      三宅 智子
    • Organizer
      第111回 日本皮膚科学会総会・学術大会
    • Place of Presentation
      京都国際会館 (京都市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] EBV関連T/NKリンパ球増殖症における皮膚病変と末梢血リンパ球サブセットについて2012

    • Author(s)
      平井 陽至
    • Organizer
      第19回ヘルペス感染症フォーラム
    • Place of Presentation
      京王プラザホテル札幌 (札幌市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 天疱瘡に合併するヘルペスウイルス感染症とその病態への関与2012

    • Author(s)
      神谷 浩二
    • Organizer
      第64回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      広島国際会議場 (広島市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヘルペスウイルス感染に伴うウイルス側・宿主側からみた免疫回避・誘導のメカニズム2012

    • Author(s)
      山本 剛伸
    • Organizer
      第8回中国研究皮膚科セミナー
    • Place of Presentation
      岡山コンベンションセンター (岡山市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Ataxia telangiectasia patients cannot cause severe Herpes Simplex because of disturbed Herpes simplex virus replication by ATM mutation2012

    • Author(s)
      Yamamoto T
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      ロワジールホテル那覇 (那覇市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] A reactivation signal, BZLF1 expression, is a prognostic marker for severe hydroa vacciniforme and hypersensitivity to mosquito bites2012

    • Author(s)
      Miyake T
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      ロワジールホテル那覇 (那覇市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Interferon gamma enhances anti-viral activity induced by double-stranded RNA in keratinocytes.2012

    • Author(s)
      Kajita A
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      ロワジールホテル那覇 (那覇市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pemphigus IgG treated keratinocytes are susceptible to herpes simplex virus induced cell dissociation, but protective to virus replication.2012

    • Author(s)
      Kamiya K
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      ロワジールホテル那覇 (那覇市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cathelicidin antimicrobial peptide LL-37 augments anti-viral activity induced by double-stranded RNA in keratinocytes.2012

    • Author(s)
      Takiguchi T
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      ロワジールホテル那覇 (那覇市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analyses of early events in primary VZV infection : New culture system to analyze primary VZV infection in human tonsil ex vivo2011

    • Author(s)
      Yamamoto T
    • Organizer
      第36回日本研究皮膚科学会学術大会
    • Place of Presentation
      国立京都国際会館,京都市
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hydroa vcciniforme is pathogenically associated with circulating Epstein-Barr virus-infected gamma-delta T-cells2011

    • Author(s)
      Hirai Y
    • Organizer
      第36回日本研究皮膚科学会学術大会
    • Place of Presentation
      国立京都国際会館,京都市
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Comparative proteomic analysis identified HSPA1A as a candidate target for enhancing apoptosis induced by histone deacetulase inhibitor2011

    • Author(s)
      Fujii K
    • Organizer
      第36回日本研究皮膚科学会学術大会
    • Place of Presentation
      国立京都国際会館,京都市
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 種痘様水疱症と蚊刺過敏症の血球リンパ球サブセットの違いについて2011

    • Author(s)
      平井陽至
    • Organizer
      中国研究皮膚科フォーラム
    • Place of Presentation
      シェラトンホテル広島,広島市
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] PROTEOMIC ANALYSIS OF HISTONE DEACETYLASE INHIBITOR SENSITIVITY IN LYMPHOID MALIGNANCIES2011

    • Author(s)
      Fujii K
    • Organizer
      HUPO2011 10th World congress
    • Place of Presentation
      Geneva Palexpo, Geneva, Switzerland
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Book] 皮膚科臨床アセット13皮膚のリンパ腫2012

    • Author(s)
      山本剛伸
    • Publisher
      中山書店
    • Related Report
      2012 Final Research Report
  • [Book] 皮膚科臨床アセット13 皮膚のリンパ腫2012

    • Author(s)
      山本 剛伸
    • Publisher
      中山書店
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-09-05   Modified: 2019-07-29  

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