Analyses of host defense mechanism with herpes virus infections

• Project/Area Number: 23890238
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kawasaki Medical School
• Principal Investigator: YAMAMOTO Takenobu 川崎医科大学, 医学部, 講師 (50379799)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ヘルペスウイルス / アポトーシス / 細胞傷害性 T 細胞 / ウイルス複製 / 細胞傷害性T細胞 / 単純ヘルペスウイルス / 水痘・帯状疱疹ウイルス / 細胞障害性T細胞 / ランゲルハンス細胞

Research Abstract

Herpes virus makes the condition which the virus grow efficiently. Herpes virus evades the host defence by minimal expression of viral antigens. On the other hand, host immune system induces cytotoxic T cell-infiltration to the skin lesions and viral infected cells apoptosis. Small vesicles are induced by herpes virus infection in health human because of the relationship between viral and host defence factors. Large vesicles are induced in the immune suppressed condition that is more predominant in viral factors than in host defence factors.

Research Products

• [Journal Article] EBV関連皮膚リンパ球増殖症 (2013)
  • Author(s): 平井陽至,山本剛伸,三宅智子,山内晶子,鈴木大介,藤井一恭,岩月啓氏
  • Journal Title: 血液内科 Volume: 66巻 Pages: 219-225
  • NAID: 40019614186
• [Journal Article] 鼻部に生じたメトトレキサート関連リンパ増殖性疾患の1例 (2012)
  • Author(s): 渡邊友也,蒲原毅,松倉節子,山本剛伸,岩月啓氏,池澤善郎
  • Journal Title: 皮膚科の臨床 Volume: 54巻 Pages: 1835-1839
  • Peer Reviewed
• [Journal Article] 伝染性単核球症おとなとこどもの症状は同じ〓Gianotti 症候群も EBV〓 (2012)
  • Author(s): 三宅智子, 平井陽至, 岩月啓氏, 山本剛伸
  • Journal Title: VisualDermatology Volume: 11巻 Pages: 1264-1266
• [Journal Article] 皮膚病変におけるウイルス感染検査と読み方 (2012)
  • Author(s): 山本剛伸
  • Journal Title: 日本皮膚科学会誌 Volume: 122巻 Pages: 3405-3408
• [Journal Article] Diversity of Epstein-Barr virus BamHI-A rightward transcripts and their expression patterns in the lytic and latent infections (2012)
  • Author(s): Yamamoto T, Iwatsuki K
  • Journal Title: J Med Microbiol Volume: 61巻 Issue: 10 Pages: 1445-1453
  • DOI: 10.1099/jmm.0.044727-0
  • Peer Reviewed
• [Journal Article] Valproic acid inhibits proliferation of EB virus-infectednatural killer cells (2012)
  • Author(s): Fujii K, Suzuki N, Yamamoto T, Duzuki D,Iwatsuki K
  • Journal Title: Hematology Volume: 17巻 Issue: 3 Pages: 163-169
  • DOI: 10.1179/102453312x13376952196494
  • Peer Reviewed
• [Journal Article] Oculomucosal and gastrointestinal involvement in Epstein-Barr virus-associated hydroa vacciniforme. (2012)
  • Author(s): Yamamoto T, Hirai Y, Miyake T, Yamasaki O, Morizane S, Iwatsuki K
  • Journal Title: Eur J Dermatol Volume: 22 Issue: 3 Pages: 380-383
  • DOI: 10.1684/ejd.2012.1665
  • Peer Reviewed
• [Journal Article] Hydroa vacciniforme is associated with increased numbers of Epstein-Barrvirus-infected γδT-cells (2012)
  • Author(s): Hirai Y, et al
  • Journal Title: Journal of Investigative Dermatology Volume: 132 Issue: 5 Pages: 1401-1408
  • DOI: 10.1038/jid.2011.461
  • Peer Reviewed
• [Journal Article] 種痘様水疱症の1例 (2012)
  • Author(s): 鈴木薫,竹中祐子,石黒直子,川島眞,平井陽至,山本剛伸,岩月啓氏
  • Journal Title: 臨床皮膚科 Volume: 66巻 Pages: 295-298
  • Peer Reviewed
• [Journal Article] Epstein-Barrウイルス感染症と種痘様水疱症 (2012)
  • Author(s): 平井陽至,山本剛伸,三宅智子,山内晶子,藤井一恭,森実真,岩月啓氏
  • Journal Title: MBDerma Volume: 191巻 Pages: 295-298
• [Journal Article] グラム染色・Tzanck 試験-コツと落とし穴- (2012)
  • Author(s): 山本剛伸
  • Journal Title: Visual Dermatology Volume: 11巻 Pages: 378-381
• [Journal Article] Proteomic study identified HSP 70kDa protein 1A as a possible therapeutic target, in combination with histone deacetylase inhibitors, for lymphoid neoplasms (2012)
  • Author(s): Fujii K, Suzuki N, Ikeda K, Hamada T,Yamamoto T, Kondo T, Iwatsuki K
  • Journal Title: JProteomics Volume: 75巻 Issue: 4 Pages: 1401-1410
  • DOI: 10.1016/j.jprot.2011.11.010
  • Peer Reviewed
• [Journal Article] Phenotypic analysis in a case of hydroa vacciniforme-like eruptions associated with chronic activeEpstein-Barr virus disease of γδ T cells (2012)
  • Author(s): Tanaka C, Hasegawa M, Fujimoto M,Iwatsuki K, Yamamoto T, Yamada K, Kawa K, Saikawa Y, Toga A, Wada T, Takehara K, Yachie A
  • Journal Title: Br J Dermatol Volume: 166巻 Issue: 1 Pages: 216-218
  • DOI: 10.1111/j.1365-2133.2011.10512.x
  • Peer Reviewed
• [Journal Article] グラム染色・Tzanck試験 -コツと落とし穴- (2012)
  • Author(s): 山本 剛伸
  • Journal Title: Visual Dermatology Volume: 11 Pages: 378-381
• [Journal Article] Epstein-Barrｳｲﾙｽ感染症と種痘様水疱症 (2012)
  • Author(s): 平井 陽至
  • Journal Title: MB Derma Volume: 191 Pages: 48-53
• [Journal Article] 種痘様水疱症の1例 (2012)
  • Author(s): 鈴木 薫
  • Journal Title: 臨床皮膚科 Volume: 66 Pages: 295-298
  • Peer Reviewed
• [Journal Article] 皮膚病変におけるウイルス感染検査と読み方 (2012)
  • Author(s): 山本 剛伸
  • Journal Title: 日本皮膚科学会雑誌 Volume: 122 Pages: 3405-3408
• [Journal Article] Proteomic study identified HSP 70kDa protein 1A as a possible therapeutic target, in combination with histone deacetylase inhibitors, for lymphoid neoplasms (2012)
  • Author(s): Fujii K
  • Journal Title: J Proteomics Volume: 75 Pages: 1401-1410
  • Peer Reviewed
• [Journal Article] 皮膚病変のウイルス感染検査 (2011)
  • Author(s): 山本剛伸
  • Journal Title: 日本皮膚科学会誌 Volume: 121巻 Pages: 2930-2933
  • NAID: 10031165077
• [Journal Article] Epstein-Barrウイルス関連T/NKリンパ球増殖症と診断した63症例の検討 (2011)
  • Author(s): 平井陽至,山本剛伸,三宅智子,山内晶子,藤井一恭,岩月啓氏
  • Journal Title: 皮膚病診療 Volume: 33巻 Pages: 1174-1178
• [Journal Article] Dendritic cell subsets and immunological milieu in inflammatory human papilloma virus-related skin lesions (2011)
  • Author(s): Nakayama Y, et al
  • Journal Title: Journal of Dermatological Science Volume: 63 Issue: 3 Pages: 173-183
  • DOI: 10.1016/j.jdermsci.2011.05.006
  • Peer Reviewed
• [Journal Article] Dendritic cell subsets and immunological milieu in inflammatory human papilloma virus-related skin lesions (2011)
  • Author(s): Nakayama Y
  • Journal Title: J Dermatol Sci Volume: 63 Pages: 173-183
  • Peer Reviewed
• [Journal Article] Epstein-Barrウイルス関連T/NKリンパ球増殖症と診断した63症例の検討 (2011)
  • Author(s): 平井陽至
  • Journal Title: 皮膚病診療 Volume: 33 Pages: 1174-1178
• [Presentation] Pathogenic cell types, molecular mechanisms and prognostic factors in EB virus-associated cutaneous T/NK lymphoproliferative disorders (2013)
  • Author(s): Iwatsuki K
  • Organizer: International Investigative Dermatology
  • Place of Presentation: Edinburgh International
• [Presentation] Eradication of cutaneousherpesvirus infections by nucleic acid sensors and cytotoxic T lymphocyte mediated apoptotic processes (2013)
  • Author(s): Hirai Y
  • Organizer: International Investigative Dermatology
  • Place of Presentation: Edinburgh International Conference Centre(EICC) (Edinburgh, Scotland)
• [Presentation] EBV関連疾患の病変部における潜伏感染の維持・再活性化メカニズムの解析 (2013)
  • Author(s): 山本剛伸
  • Organizer: 第22回EBウイルス感染症研究会
  • Place of Presentation: ベルサール八重洲(東京)
• [Presentation] Immediate-early (IE) genereactivation signal, BZLF1, is a molecular marker for a poor prognosis of EBV-associated T/NKlymphoproliferative skin diseases (2013)
  • Author(s): Iwatsuki K
  • Organizer: 2nd World Congress ofCutaneous Lymphomas
  • Place of Presentation: MCI Deutschland GmbH(Berlin)
• [Presentation] VZV・HSV感染に伴う多彩な皮膚臨床像について (2013)
  • Author(s): 山本剛伸
  • Organizer: 第5回HZ・S研究会
  • Place of Presentation: ストリングスホテル東京インターコンチネンタル(東京)
• [Presentation] VZV・HSV感染に伴う多彩な皮膚臨床像について (2013)
  • Author(s): 山本 剛伸
  • Organizer: 第5回 HZ・S研究会
  • Place of Presentation: ストリングスホテル東京インターコンチネンタル (東京)
• [Presentation] Immediate-early (IE) gene reactivation signal, BZLF1, is a molecular marker for a poor prognosis of EBV-associated T/NKlymphoproliferative skin diseases (2013)
  • Author(s): Iwatsuki K
  • Organizer: 2nd World Congress of Cutaneous Lymphomas
  • Place of Presentation: MCI Deutschland GmbH (Berlin)
• [Presentation] EBV関連疾患の病変部における潜伏感染の維持・再活性化メカニズムの解析 (2013)
  • Author(s): 山本 剛伸
  • Organizer: 第22回 EBウイルス感染症研究会
  • Place of Presentation: ベルサール八重洲 (東京)
• [Presentation] Eradication of cutaneous herpesvirus infections by nucleic acid sensors and cytotoxic T lymphocyte-mediated apoptotic processes (2013)
  • Author(s): Hirai Y
  • Organizer: International Investigative Dermatology
  • Place of Presentation: Edinburgh International Conference Centre (EICC) (Edinburgh, Scotland)
• [Presentation] Pathogenic cell types, molecular mechanisms and prognostic factors in EB virus-associated cutaneous T/NK lymphoproliferative disorders (2013)
  • Author(s): Iwatsuki K
  • Organizer: International Investigative Dermatology
  • Place of Presentation: Edinburgh International Conference Centre (EICC) (Edinburgh, Scotland)
• [Presentation] EBウイルス関連疾患の予後に関する追跡調査 (2012)
  • Author(s): 三宅智子
  • Organizer: EBウイルス感染症研究会
  • Place of Presentation: ベルサール八重洲.東京都中央区
  • Year and Date: 2012-03-17
• [Presentation] 免疫能と皮疹形成のメカニズム-単純疱疹と帯状疱疹の共通点・相違点- (2012)
  • Author(s): 山本剛伸
  • Organizer: 第4回HZ研究会
  • Place of Presentation: ストリングホテル東京インターコンチネンタル,東京港区(招待講演)
  • Year and Date: 2012-01-28
• [Presentation] Cathelicidin antimicrobialpeptide LL-37 augments anti-viralactivity induced by double-stranded RNA in keratinocytes (2012)
  • Author(s): Takiguchi T
  • Organizer: The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ロワジールホテル那覇 (那覇市)
• [Presentation] Pemphigus IgG treated keratinocytes are susceptible to herpes simplex virus induced cell dissociation, but protective to virus replication (2012)
  • Author(s): Kamiya K
  • Organizer: The37th Annual Meeting of the JapaneseSociety for Investigative Dermatology
  • Place of Presentation: ロワジールホテル那覇 (那覇市)
• [Presentation] Interferon gamma enhancesanti-viral activity induced by double-stranded RNA in keratinocytes (2012)
  • Author(s): Kajita A
  • Organizer: The37th Annual Meeting of the JapaneseSociety for Investigative Dermatology
  • Place of Presentation: ロワジールホテル那覇(那覇市)
• [Presentation] A reactivation signal, BZLF1expression, is a prognostic marker for severe hydroa vacciniforme and hypersensitivity to mosquito bites (2012)
  • Author(s): Miyake T
  • Organizer: The37th Annual Meeting of the JapaneseSociety for Investigative Dermatology
  • Place of Presentation: ロワジールホテル那覇(那覇市)
• [Presentation] Ataxia telangiectasiapatients cannot cause severe Herpes Simplex because of disturbed Herpes simplex virus replication by ATM mutation (2012)
  • Author(s): Yamamoto T
  • Organizer: The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ロワジールホテル那覇(那覇市)
• [Presentation] ヘルペスウイルス感染に伴うウイルス側・宿主側からみた免疫回避・誘導のメカニズム (2012)
  • Author(s): 山本剛伸
  • Organizer: 第8回中国研究皮膚科セミナー
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
• [Presentation] 天疱瘡に合併するヘルペスウイルス感染症とその病態への関与 (2012)
  • Author(s): 神谷浩二
  • Organizer: 第64回日本皮膚科学会西部支部学術大会
  • Place of Presentation: 広島国際会議場(広島市)
• [Presentation] EBV関連T/NKリンパ球増殖症における皮膚病変と末梢血リンパ球サブセットについて (2012)
  • Author(s): 平井陽至
  • Organizer: 第19回ヘルペス感染症フォーラム
  • Place of Presentation: 京王プラザホテル札幌(札幌市)
• [Presentation] EBウイルス関連疾患の予後に関する追跡調査 (2012)
  • Author(s): 三宅智子
  • Organizer: 第111回日本皮膚科学会総会・学術大会
  • Place of Presentation: 京都国際会館(京都市)
• [Presentation] 皮膚病変におけるウイルス感染検査と読み方 (2012)
  • Author(s): 山本剛伸
  • Organizer: 第111回日本皮膚科学会総会・学術大会
  • Place of Presentation: 京都国際会館(京都市)
• [Presentation] Clues for Epstein-Barr virusreactivation with the subsequent outbreak of immune responses in skin lesions of hypersensitivity to mosquito bites (2012)
  • Author(s): Iwatsuki K
  • Organizer: SID72th Annual Meeting
  • Place of Presentation: Raleigh ConventionCenter (Raleigh, North Carolina)
• [Presentation] Clues for Epstein-Barr virus reactivation with the subsequent outbreak of immune responses in skin lesions of hypersensitivity to mosquito bites. (2012)
  • Author(s): Iwatsuki K
  • Organizer: SID 72th Annual Meeting
  • Place of Presentation: Raleigh Convention Center (Raleigh, North Carolina)
• [Presentation] 皮膚病変におけるウイルス感染検査と読み方 (2012)
  • Author(s): 山本 剛伸
  • Organizer: 第111回 日本皮膚科学会総会・学術大会
  • Place of Presentation: 京都国際会館 (京都市)
  • Invited
• [Presentation] EBウイルス関連疾患の予後に関する追跡調査 (2012)
  • Author(s): 三宅 智子
  • Organizer: 第111回 日本皮膚科学会総会・学術大会
  • Place of Presentation: 京都国際会館 (京都市)
• [Presentation] EBV関連T/NKリンパ球増殖症における皮膚病変と末梢血リンパ球サブセットについて (2012)
  • Author(s): 平井 陽至
  • Organizer: 第19回ヘルペス感染症フォーラム
  • Place of Presentation: 京王プラザホテル札幌 (札幌市)
  • Invited
• [Presentation] 天疱瘡に合併するヘルペスウイルス感染症とその病態への関与 (2012)
  • Author(s): 神谷 浩二
  • Organizer: 第64回日本皮膚科学会西部支部学術大会
  • Place of Presentation: 広島国際会議場 (広島市)
• [Presentation] ヘルペスウイルス感染に伴うウイルス側・宿主側からみた免疫回避・誘導のメカニズム (2012)
  • Author(s): 山本 剛伸
  • Organizer: 第8回中国研究皮膚科セミナー
  • Place of Presentation: 岡山コンベンションセンター (岡山市)
• [Presentation] Ataxia telangiectasia patients cannot cause severe Herpes Simplex because of disturbed Herpes simplex virus replication by ATM mutation (2012)
  • Author(s): Yamamoto T
  • Organizer: The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ロワジールホテル那覇 (那覇市)
• [Presentation] A reactivation signal, BZLF1 expression, is a prognostic marker for severe hydroa vacciniforme and hypersensitivity to mosquito bites (2012)
  • Author(s): Miyake T
  • Organizer: The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ロワジールホテル那覇 (那覇市)
• [Presentation] Interferon gamma enhances anti-viral activity induced by double-stranded RNA in keratinocytes. (2012)
  • Author(s): Kajita A
  • Organizer: The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ロワジールホテル那覇 (那覇市)
• [Presentation] Pemphigus IgG treated keratinocytes are susceptible to herpes simplex virus induced cell dissociation, but protective to virus replication. (2012)
  • Author(s): Kamiya K
  • Organizer: The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ロワジールホテル那覇 (那覇市)
• [Presentation] Cathelicidin antimicrobial peptide LL-37 augments anti-viral activity induced by double-stranded RNA in keratinocytes. (2012)
  • Author(s): Takiguchi T
  • Organizer: The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ロワジールホテル那覇 (那覇市)
• [Presentation] Analyses of early events in primary VZV infection : New culture system to analyze primary VZV infection in human tonsil ex vivo (2011)
  • Author(s): Yamamoto T
  • Organizer: 第36回日本研究皮膚科学会学術大会
  • Place of Presentation: 国立京都国際会館,京都市
  • Year and Date: 2011-12-10
• [Presentation] Hydroa vcciniforme is pathogenically associated with circulating Epstein-Barr virus-infected gamma-delta T-cells (2011)
  • Author(s): Hirai Y
  • Organizer: 第36回日本研究皮膚科学会学術大会
  • Place of Presentation: 国立京都国際会館,京都市
  • Year and Date: 2011-12-10
• [Presentation] Comparative proteomic analysis identified HSPA1A as a candidate target for enhancing apoptosis induced by histone deacetulase inhibitor (2011)
  • Author(s): Fujii K
  • Organizer: 第36回日本研究皮膚科学会学術大会
  • Place of Presentation: 国立京都国際会館,京都市
  • Year and Date: 2011-12-10
• [Presentation] 種痘様水疱症と蚊刺過敏症の血球リンパ球サブセットの違いについて (2011)
  • Author(s): 平井陽至
  • Organizer: 中国研究皮膚科フォーラム
  • Place of Presentation: シェラトンホテル広島,広島市
  • Year and Date: 2011-11-05
• [Presentation] PROTEOMIC ANALYSIS OF HISTONE DEACETYLASE INHIBITOR SENSITIVITY IN LYMPHOID MALIGNANCIES (2011)
  • Author(s): Fujii K
  • Organizer: HUPO2011 10th World congress
  • Place of Presentation: Geneva Palexpo, Geneva, Switzerland
  • Year and Date: 2011-09-06
• [Book] 皮膚科臨床アセット13皮膚のリンパ腫 (2012)
  • Author(s): 山本剛伸
  • Publisher: 中山書店
• [Book] 皮膚科臨床アセット13 皮膚のリンパ腫 (2012)
  • Author(s): 山本 剛伸
  • Publisher: 中山書店