Analyses of host defense mechanism with herpes virus infections
| Project/Area Number |
23890238
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ヘルペスウイルス / アポトーシス / 細胞傷害性 T 細胞 / ウイルス複製 / 細胞傷害性T細胞 / 単純ヘルペスウイルス / 水痘・帯状疱疹ウイルス / 細胞障害性T細胞 / ランゲルハンス細胞 |
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| Research Abstract |
Herpes virus makes the condition which the virus grow efficiently. Herpes virus evades the host defence by minimal expression of viral antigens. On the other hand, host immune system induces cytotoxic T cell-infiltration to the skin lesions and viral infected cells apoptosis. Small vesicles are induced by herpes virus infection in health human because of the relationship between viral and host defence factors. Large vesicles are induced in the immune suppressed condition that is more predominant in viral factors than in host defence factors.
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Report
(3 results)
Research Products
(64 results)
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[Journal Article] Phenotypic analysis in a case of hydroa vacciniforme-like eruptions associated with chronic activeEpstein-Barr virus disease of γδ T cells2012
Author(s)
Tanaka C, Hasegawa M, Fujimoto M,Iwatsuki K, Yamamoto T, Yamada K, Kawa K, Saikawa Y, Toga A, Wada T, Takehara K, Yachie A
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Journal Title
Br J Dermatol
Volume: 166巻
Issue: 1
Pages: 216-218
DOI
Related Report
Peer Reviewed
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