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Analyses on the progression of liver fibrosis induced by hepatitis B virus infection

Research Project

Project/Area Number 23890255
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionResearch Institute, International Medical Center of Japan

Principal Investigator

SUGIYAMA Masaya  独立行政法人国立国際医療研究センター, 肝炎・免疫研究センター, 肝疾患研究部 (20612427)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsB型肝炎ウイルス / 肝線維化 / 自然免疫 / 活性酸素種 / 細胞周期 / ヒト肝細胞キメラマウス
Research Abstract

Chimeric mice with human hepatocyte was infected with hepatitis B virus to mimic liver fibrosis triggered by virus infection. To prevent liver fibrosis, a newly developed antibody specific for Toll-like receptor 4 was administrated with the chimeric mice. The antibody successfully prevented the progression of liver fibrosis. The severe side effect induced by the antibody was not observed in the mice. Along with these results, the antibody could be a potential as a new drug. Further study is needed to reveal the molecular basis of this effect.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • Research Products

    (66 results)

All 2013 2012 2011

All Journal Article (34 results) (of which Peer Reviewed: 17 results) Presentation (27 results) Book (1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Journal Article] 2'-Fluoro-6'-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: In vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action.2013

    • Author(s)
      Rawal RK, Singh US, Chavre SN, Wang J, Sugiyama M, Hung W, Govindarajan R, Korba B, Tanaka Y, Chu CK
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 23(2) Pages: 503-6

    • Related Report
      2012 Final Research Report
  • [Journal Article] 2'-Fluoro-6'-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug : In vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action.2013

    • Author(s)
      Rawal RK, Singh US, Chavre SN, Wang J, Sugiyama M, Hung W, Govindarajan R, Korba B, Tanaka Y, Chu CK.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 15 Issue: 2 Pages: 503-6

    • DOI

      10.1016/j.bmcl.2012.11.027

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene.2012

    • Author(s)
      Watanabe T, Sugauchi F, Tanaka Y, Matsuura K, Yatsuhashi H, Murakami S, Iijima S, Iio E, Sugiyama M, Shimada T, Kakuni M, Kohara M, Mizokami M
    • Journal Title

      Gut

    • Related Report
      2012 Final Research Report
  • [Journal Article] Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma.2012

    • Author(s)
      Kumar V, Yi Lo PH, Sawai H, Kato N, Takahashi A, Deng Z, Urabe Y, Mbarek H, Tokunaga K, Tanaka Y, Sugiyama M, Mizokami M, Muroyama R, Tateishi R, Omata M, Koike K, Tanikawa C, Kamatani N, Kubo M, Nakamura Y, Matsuda K
    • Journal Title

      PLoS One

      Volume: 7(9)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.2012

    • Author(s)
      Nishida N, Sawai H, Matsuura K, Sugiyama M, Ahn SH, Park JY, Hige S, Kang JH, Suzuki K, Kurosaki M, Asahina Y, Mochida S, Watanabe M, Tanaka E, Honda M, Kaneko S, Orito E, Itoh Y, Mita E, Tamori A, Murawaki Y, Hiasa Y, Sakaida I, Korenaga M, Hino K, Ide T, Kawashima M, Mawatari Y, Sageshima M, Ogasawara Y, Koike A, Izumi N, Han KH, Tanaka Y, Tokunaga K, Mizokami M
    • Journal Title

      PLoS One

      Volume: 7(6)

    • Related Report
      2012 Final Research Report
  • [Journal Article] No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations.2012

    • Author(s)
      Sawai H, Nishida N, Mbarek H, Matsuda K, Mawatari Y, Yamaoka M, Hige S, Kang JH, Abe K, Mochida S, Watanabe M, Kurosaki M, Asahina Y, Izumi N, Honda M, Kaneko S, Tanaka E, Matsuura K, Itoh Y, Mita E, Korenaga M, Hino K, Murawaki Y, Hiasa Y, Ide T, Ito K, Sugiyama M, Ahn SH, Han KH, Park JY, Yuen MF, Nakamura Y, Tanaka Y, Mizokami M, Tokunaga K
    • Journal Title

      BMC Med Genet

      Volume: 13 Pages: 47-47

    • Related Report
      2012 Final Research Report
  • [Journal Article] Development of specific and quantitative real-time detection PCR and immunoassays for λ3-interferon.2012

    • Author(s)
      Sugiyama M, Kimura T, Naito S, Mukaide M, Shinauchi T, Ueno M, Ito K, Murata K, Mizokami M
    • Journal Title

      Hepatol Res.

      Volume: 42(11) Pages: 1089-99

    • Related Report
      2012 Final Research Report
  • [Journal Article] Factors responsible for the discrepancy between IL28B polymorphism prediction and the viral response to peginterferon plus ribavirin therapy in Japanese chronic hepatitis C patients.2012

    • Author(s)
      Saito H, Ito K, Sugiyama M, Matsui T, Aoki Y, Imamura M, Murata K, Masaki N, Nomura H, Adachi H, Hige S, Enomoto N, Sakamoto N, Kurosaki M, Mizokami M, Watanabe S
    • Journal Title

      Hepatol Res.

      Volume: 42(10) Pages: 958-965

    • Related Report
      2012 Final Research Report
  • [Journal Article] LecT-hepa, a glyco-marker derived from multiple lectins, as a predictor of liver fibrosis in chronic hepatitis C patients.2012

    • Author(s)
      Ito K, Kuno A, Ikehara Y, Sugiyama M, Saito H, Aoki Y, Matsui T, Imamura M, Korenaga M, Murata K, Masaki N, Tanaka Y, Hige S, Izumi N, Kurosaki M, Nishiguchi S, Sakamoto M, Kage M, Narimatsu H, Mizokami M.
    • Journal Title

      Hepatology.

      Volume: 56(4) Pages: 1448-56

    • Related Report
      2012 Final Research Report
  • [Journal Article] Present state and the future direction of HBV vaccine2012

    • Author(s)
      Mizokami M, Sugiyama M.
    • Journal Title

      Uirusu

      Volume: 62 Pages: 67-77

    • NAID

      10030768091

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma.2012

    • Author(s)
      Kumar V, Yi Lo PH, Sawai H, Kato N, Takahashi A, Deng Z, Urabe Y, Mbarek H, Tokunaga K, Tanaka Y, Sugiyama M, Mizokami M, Muroyama R, Tateishi R, Omata M, Koike K, Tanikawa C, Kamatani N, Kubo M, Nakamura Y, Matsuda K.
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.2012

    • Author(s)
      Nishida N, Sawai H, Matsuura K, Sugiyama M, Ahn SH, Park JY, Hige S, Kang JH, Suzuki K, Kurosaki M, Asahina Y, Mochida S, Watanabe M, Tanaka E, Honda M, Kaneko S, Orito E, Itoh Y, Mita E, Tamori A, Murawaki Y, Hiasa Y, Sakaida I, Korenaga M, Hino K, Ide T, Kawashima M, Mawatari Y, Sageshima M, Ogasawara Y, Koike A, Izumi N, Han KH, Tanaka Y, Tokunaga K, Mizokami M.
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations.2012

    • Author(s)
      Sawai H, Nishida N, Mbarek H, Matsuda K, Mawatari Y, Yamaoka M, Hige S, Kang JH, Abe K, Mochida S, Watanabe M, Kurosaki M, Asahina y Izumi N, Honda M, Kaneko S, Tanaka E, Matsuura K, Itoh Y, Mita E, Korenaga M, Hino K, Murawaki Y, Hiasa Y, Ide T, Ito K, Sugiyama M, Ahn SH, Han KH, Park JY, Yuen MF, Nakamura Y, Tanaka Y, Mizokami M, Tokunaga K.
    • Journal Title

      BMC Med Genet.

      Volume: 19 Pages: 47-47

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of specific and quantitative real-time detection PCR and immunoassays for λ3-interferon2012

    • Author(s)
      Sugiyama M, Kimura T, Naito S, Mukaide M, Shinauchi T, Ueno M, Ito K, Murata K, Mizokami M
    • Journal Title

      Hepatol Res

      Volume: 42(11) Issue: 11 Pages: 1089-99

    • DOI

      10.1111/j.1872-034x.2012.01032.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors responsible for the discrepancy between IL28B polymorphism prediction and the viral response to peginterferon plus ribavirin therapy in Japanese chronic hepatitis C patients2012

    • Author(s)
      Saito H, Ito K, Sugiyama M, Matsui T, Aoki Y, Imamura M, Murata K, Masaki N, Nomura H, Adachi H, Hige S, Enomoto N, Sakamoto N, Kurosaki M, Mizokami M, Watanabe S
    • Journal Title

      Hepatol Res

      Volume: 42(10) Issue: 10 Pages: 958-65

    • DOI

      10.1111/j.1872-034x.2012.01013.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LecT-Hepa, a glyco-marker derived from multiple lectins, as a predictor of liver fibrosis in chronic hepatitis C patients2012

    • Author(s)
      Ito K, Kuno A, Ikehara Y, Sugiyama M, Saito H, Aoki Y, Matsui T, Imamura M, Korenaga M, Murata K, Masaki N, Tanaka Y, Hige S, Izumi N, Kurosaki M, Nishiguchi S, Sakamoto M, Kage M, Narimatsu H, Mizokami M
    • Journal Title

      Hepatology

      Volume: 56 Issue: 4 Pages: 1448-56

    • DOI

      10.1002/hep.25815

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Variation of the IL-28B Promoter Affecting Gene Expression.2011

    • Author(s)
      Sugiyama M, Tanaka Y, Wakita T, Nakanishi M, Mizokami M
    • Journal Title

      PLoS ONE

      Volume: 6(10)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Easy-to-use phylogenetic analysis system for hepatitis B virus infection.2011

    • Author(s)
      Sugiyama M, Inui A, Shin-I T, Komatsu H, Mukaide M, Masaki N, Murata K, Ito K, Nakanishi M, Fujisawa T, Mizokami M
    • Journal Title

      Hepatol Res.

      Volume: 41(10) Pages: 936-45

    • Related Report
      2012 Final Research Report
  • [Journal Article] Novel findings for the development of drug therapy for various liver diseases: Genetic variation in IL-28B is associated with response to the therapy for chronic hepatitis C.2011

    • Author(s)
      Sugiyama M, Tanaka Y, Nakanishi M, Mizokami M
    • Journal Title

      J Pharmacol Sci.

      Volume: 115(3) Pages: 263-9

    • Related Report
      2012 Final Research Report
  • [Journal Article] Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors.2011

    • Author(s)
      Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Honda M, Sugiyama M, Matsuura K, Sugauchi F, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Sakai A, Kaneko S, Ito K, Masaki N, Tokunaga K, Izumi N, Mizokami M
    • Journal Title

      J Hepatol

      Volume: 54(3) Pages: 439-48

    • Related Report
      2012 Final Research Report
  • [Journal Article] Transmissibility of hepatitis B virus (HBV) infection through blood transfusion from blood donors with occult HBV infection.2011

    • Author(s)
      Yuen MF, Wong DK, Lee CK, Tanaka Y, Allain JP, Fung J, Leung J, Lin CK, Sugiyama M, Sugauchi F, Mizokami M, Lai CL
    • Journal Title

      Clin Infect Dis.

      Volume: 52(5) Pages: 624-32

    • Related Report
      2012 Final Research Report
  • [Journal Article] Host sphingolipid biosynthesis is a promising therapeutic target for the inhibition of hepatitis B virus replication.2011

    • Author(s)
      Tatematsu K, Tanaka Y, Sugiyama M, Sudoh M, Mizokami M.
    • Journal Title

      J Med Virol

      Volume: 83(4) Pages: 587-93

    • Related Report
      2012 Final Research Report
  • [Journal Article] Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C.2011

    • Author(s)
      Tanaka Y, Kurosaki M, Nishida N, Sugiyama M, Matsuura K, Sakamoto N, Enomoto N, Yatsuhashi H, Nishiguchi S, Hino K, Hige S, Itoh Y, Tanaka E, Mochida S, Honda M, Hiasa Y, Koike A, Sugauchi F, Kaneko S, Izumi N, Tokunaga K, Mizokami M
    • Journal Title

      Hum Mol Genet

      Volume: 20(17) Pages: 3507-16

    • Related Report
      2012 Final Research Report
  • [Journal Article] Antiviral activity of novel 2'-fluoro-6'-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants.2011

    • Author(s)
      Wang J, Singh US, Rawal RK, Sugiyama M, Yoo J, Jha AK, Scroggin M, Huang Z, Murray MG, Govindarajan R, Tanaka Y, Korba B, Chu CK
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 21(21) Pages: 6328-31

    • Related Report
      2012 Final Research Report
  • [Journal Article] An updated analysis of hepatitis C virus genotypes and subtypes based on the complete coding region.2011

    • Author(s)
      Nakano T, Lau GM, Lau GM, Sugiyama M, Mizokami M
    • Journal Title

      Liver Int.

    • Related Report
      2012 Final Research Report
  • [Journal Article] Genetic Variation of the IL-28B promoter affecting gene expression2011

    • Author(s)
      Masaya Sugiyama, 他4名
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Easy-to-use phylogenetic analysis system for hepatitis B virus infection2011

    • Author(s)
      Sugiyama M, Inui A, Shin-IT, Komatsu H, Mukaide M, Masaki N, Murata K, Ito K, Nakanishi M, Fujisawa T, Mizokami M
    • Journal Title

      Hepatol Res

      Volume: 41(10) Issue: 10 Pages: 936-945

    • DOI

      10.1111/j.1872-034x.2011.00859.x

    • NAID

      10031144168

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel findings for the development of drug therapy for various liver diseases : Genetic variation in IL-28B is associated with response to the therapy for chronic hepatitis C2011

    • Author(s)
      Masaya Sugiyama, 他4名
    • Journal Title

      Journal of Pharmacological Science

      Volume: 115 Pages: 263-269

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors2011

    • Author(s)
      Masayuki Kurosaki, Masaya Sugiyama, 他19名
    • Journal Title

      Journal of Hepatology

      Volume: 54 Pages: 439-448

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transmissibility of hepatitis B virus (HBV) infection through blood transfusion from blood donors with occult HBV infection2011

    • Author(s)
      Man-Fung Yuen, Masaya Sugiyama, 他10名
    • Journal Title

      Clinical Infectious Diseases

      Volume: 52 Pages: 624-632

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host sphingolipid biosynthesis is a promising therapeutic target for the inhibition of hepatitis B virus replication2011

    • Author(s)
      Tatematsu K, Mizokami M, et al
    • Journal Title

      Journal of Medical Virology

      Volume: 83 Issue: 4 Pages: 587-593

    • DOI

      10.1002/jmv.21970

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C2011

    • Author(s)
      Yasuhito Tanaka, Masaya Sugiyama, 他20名
    • Journal Title

      Human Molecular Genetics

      Volume: 20 Pages: 3507-3516

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiviral activity of novel 2'-fluoro-6'-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants2011

    • Author(s)
      Jianing Wang, Masaya Sugiyama, 他11名
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 21 Pages: 6328-6331

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An updated analysis of hepatitis C virus genotypes and subtypes based on the complete coding region2011

    • Author(s)
      Nakano T, Mizokami M, et al
    • Journal Title

      Liver International

      Volume: 32 Issue: 2 Pages: 339-345

    • DOI

      10.1111/j.1478-3231.2011.02684.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規スフィンゴ脂質合成経路阻害剤によるHBV増殖抑制効果2012

    • Author(s)
      杉山真也
    • Organizer
      Hepatology Meeting in Japan 2012
    • Place of Presentation
      椿山荘
    • Year and Date
      2012-10-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genetic variation in IL-28B promoter region consisting of TA dinucleotide repeat could improve the prediction of chronic hepatitis C and spontaneous clearance with rs8099917 genotyping.2012

    • Author(s)
      」Masaya Sugiyama, Akio Ido, Hirohito Tsubouchi, Hisayoshi Watanabe, Yoshiyuki Ueno, and Masashi Mizokami
    • Organizer
      American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston(Poster P-1765)
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Genetic variation in IL-28B promoter region consisting of TA dinucleotide repeat could improve the prediction of chronic hepatitis C and spontaneous clearance with rs8099917 genotyping.2012

    • Author(s)
      Masaya Sugiyama, Akio Ido, Hirohito Tsubouchi, Hisayoshi Watanabe, Yoshiyuki Ueno, Masashi Mizokami
    • Organizer
      American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] The influence of specific mutations observed in core promoter region of HBV genotype D1 on viral replication.2012

    • Author(s)
      Masaya Sugiyama, Yasuhito Tanaka, Makoto Nakanishi and Masashi Mizokami
    • Organizer
      2012 International Meeting on Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Oxford, England(Poster P-109)
    • Year and Date
      2012-09-25
    • Related Report
      2012 Final Research Report
  • [Presentation] The influence of specific mutations observed in core promoter region of HBV genotype D1 on viral replication.2012

    • Author(s)
      Masaya Sugiyama, Yasuhito Tanaka, Makoto Nakanishi, Masashi Mizokami
    • Organizer
      International Meeting on Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Oxford
    • Year and Date
      2012-09-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] IL-28B周囲にあるSNPsの機能解析とその意義2012

    • Author(s)
      杉山真也
    • Organizer
      第4回東葛・城東肝疾患研究会
    • Place of Presentation
      船橋グランドホテル
    • Year and Date
      2012-07-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] IL28B特異的測定系の開発と臨床的意義の検討2012

    • Author(s)
      杉山真也,村田一素,溝上雅史
    • Organizer
      シンポジウムS1-1 第77階日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      神戸商工会議所 神戸
    • Year and Date
      2012-06-21
    • Related Report
      2012 Final Research Report
  • [Presentation] IL28B特異的測定系の開発と臨床的意義の検討2012

    • Author(s)
      杉山真也, 村田一素, 溝上雅史
    • Organizer
      第77階日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      神戸商工会議所
    • Year and Date
      2012-06-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] C型慢性肝炎と自然治癒に関連する第二遺伝要因の探索とその応用2012

    • Author(s)
      杉山真也、平峯智、西田奈央、伊藤清顕、村田一素、正木尚彦、井戸章雄、坪内博仁、溝上雅史
    • Organizer
      ワークショップWS25-3 第48回日本肝臓学会総会
    • Place of Presentation
      ポルテ金沢 金沢
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] C型慢性肝炎と自然治癒に関連する第二遺伝要因の探索とその応用2012

    • Author(s)
      杉山真也、平峯智、西田奈央、伊藤清顕、村田一素、正木尚彦、井戸章雄、坪内博仁、溝上雅史
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      ポルテ金沢
    • Year and Date
      2012-06-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] 活性酸素種を中心としたB型肝炎ウイルスの病態進展に関わる分子機序の解析2012

    • Author(s)
      杉山真也、田中靖人、溝上雅史
    • Organizer
      シンポジウムS4 Liver forum in Kyoto第14回学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] スフィンゴ脂質合成経路の阻害によるHBV複製の抑制2012

    • Author(s)
      」杉山真也、田中靖人、溝上雅史
    • Organizer
      肝炎ウイルス研究シンポジウムS4
    • Place of Presentation
      東京
    • Year and Date
      2012-03-24
    • Related Report
      2012 Final Research Report
  • [Presentation] スフィンゴ脂質合成経路の阻害によるHBV複製の抑制2012

    • Author(s)
      杉山真也、田中靖人、溝上雅史
    • Organizer
      肝炎ウイルス研究シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-03-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 宿主・ウイルスゲノム解析によるC型肝炎の病態解明にむけて"Host and viral genome analyses on hepatitis C"2012

    • Author(s)
      杉山真也
    • Organizer
      ワークショップB1 国立遺伝学研究所研究会 NIG Workshop
    • Place of Presentation
      国立遺伝学研究所 三島
    • Year and Date
      2012-03-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 宿主・ウイルスゲノム解析によるC型肝炎の病態解明にむけて"Host and viral genome analyses On hepatitis C"2012

    • Author(s)
      杉山真也
    • Organizer
      国立遺伝学研究所研究会NIG Workshop
    • Place of Presentation
      国立遺伝学研究所
    • Year and Date
      2012-03-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] No infectivity of HBV DNA and HBsAb double-positive sera in uPA/SCID chimeric mouse2012

    • Author(s)
      Masaya Sugiyama, Miki Yoshida, Yuji Hoshi, Yasumi Furui, Shigeharu Uchida, Masashi Mizokami
    • Organizer
      sian Pacific Association for the Study of the Liver
    • Place of Presentation
      Taipei, Taiwan(Poster PP10-010)
    • Year and Date
      2012-02-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Core promoter mutations specific for hepatitis B virus genotype D1 regulating viral replication2012

    • Author(s)
      Masaya Sugiyama, Sachiko Sato, Yasuhito Tanaka, Kiyoaki Ito, Kazumoto Murata, Naohiko Masaki, and Masashi Mizokami
    • Organizer
      Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Taipei, Taiwan(Poster PP10-017)
    • Year and Date
      2012-02-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Host sphingolipid biosynthesis as a therapeutic target for HBV replication2011

    • Author(s)
      Makoto Nakanishi, Masayuki Sudoh, and Masashi Mizokami
    • Organizer
      American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco(Poster P-1462)
    • Year and Date
      2011-11-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Polymorphism of IL-28B promoter region could improve the prediction value of response to CHC treatment following rs8099917 genotyping.2011

    • Author(s)
      Masaya Sugiyama, Yasuhito Tanaka, Masashi Mizokami
    • Organizer
      American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco(Poster P-407)
    • Year and Date
      2011-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] ホストのスフィンゴ脂質合成系を標的とした抗HBV薬のキメラマウスにおける検討2011

    • Author(s)
      杉山真也、田中靖人、溝上雅史
    • Organizer
      パネルディスカッションPD4-3 第19回日本消化器関連学会週間
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-20
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-28B遺伝子周囲に存在するSNPsの機能解析と臨床的意義2011

    • Author(s)
      杉山真也、田中靖人、溝上雅史
    • Organizer
      シンポジウムS2-13 第19回日本消化器関連学会週間
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-20
    • Related Report
      2012 Final Research Report
  • [Presentation] ホストのスフィンゴ脂質合成系を標的とした抗HBV薬のキメラマウスにおける検討2011

    • Author(s)
      杉山真也、田中靖人、溝上雅史
    • Organizer
      第19回日本消化器関連学会週間
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-28B遺伝子周囲に存在するSNPsの機能解析と臨床的意義2011

    • Author(s)
      杉山真也、田中靖人、溝上雅史
    • Organizer
      第19回日本消化器関連学会週間
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] The impact of core promoter mutations specific for hepatitis B virus genotype D1 on viral replication2011

    • Author(s)
      Masaya Sugiyama, Yasuhito Tanaka, Makoto Nakanishi, and Masashi Mizokami
    • Organizer
      Asian Pacific Digestive Week 2011
    • Place of Presentation
      Singapore(Poster 848)
    • Year and Date
      2011-10-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Influence of genetic variation in IL-28B promoter on the gene expression levels2011

    • Author(s)
      Masaya Sugiyama, Yasuhito Tanaka, Makoto Nakanishi, and Masashi Mizokami
    • Organizer
      International Union of Microbiological Societies Congresses 2011
    • Place of Presentation
      Sapporo(Poster VI-PO18-6)
    • Year and Date
      2011-09-13
    • Related Report
      2012 Final Research Report
  • [Presentation] キメラマウスでのB型肝炎の病態進展に関わる分子機構の検討2011

    • Author(s)
      杉山真也、田中靖人、溝上雅史
    • Organizer
      シンポジウムSY-1-11 第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-02
    • Related Report
      2012 Final Research Report
  • [Presentation] キメラマウスでのB型肝炎の病態進展に関わる分子機構の検討2011

    • Author(s)
      杉山真也、田中靖人、溝上雅史
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report
  • [Book] ゲノムワイド関連解析とその応用2011

    • Author(s)
      杉山真也、溝上雅史
    • Total Pages
      6
    • Publisher
      新時代のウイルス性肝炎学
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] C型肝炎患者の経過予測方法2011

    • Inventor(s)
      溝上雅史、杉山真也
    • Industrial Property Rights Holder
      国立国際医療研究センター
    • Industrial Property Number
      2011-211647
    • Filing Date
      2011-09-27
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Patent(Industrial Property Rights)] B型肝炎ウイルス群を検出し、遺伝子多様性を評価するためのオリゴヌクレオチドのセット、並びにそれを用いた方法2011

    • Inventor(s)
      溝上雅史、杉山真也、新井 理、田村卓郎
    • Industrial Property Rights Holder
      国立国際医療研究センター,ビッツ株式会社
    • Filing Date
      2011-12-19
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] IL-28Bの分析方法2011

    • Inventor(s)
      溝上雅史、杉山真也、木村達治
    • Industrial Property Rights Holder
      国立国際医療研究センター、特殊免疫研究所
    • Industrial Property Number
      2011-287603
    • Filing Date
      2011-12-28
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Patent(Industrial Property Rights)] B型肝炎ウイルス群を検出し、遺伝子多様性を評価するためのオリゴヌクレオチドのセット、並びにそれを用いた方法2011

    • Inventor(s)
      溝上雅史、杉山真也、新井理、田村卓郎
    • Industrial Property Rights Holder
      国立国際医療研究センター、ビッツ株式会社
    • Filing Date
      2011-12-19
    • Related Report
      2011 Annual Research Report
    • Overseas

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Published: 2011-09-05   Modified: 2019-07-29  

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